474012-67-4

Upstream product

• 1072-97-5 5-bromo-2-pyridylamine 
• 37904-72-6 2-bromo-1-(4-(dimethylamino)phenyl)ethanone 

Downstream Products

• 14954-72-4 2-(4′-dimethylaminophenyl)-6-imidazo[1,2-a]pyridine 
• 474012-72-1 2-[4'-(N,N-dimethylamino)phenyl]-6-tributylstannylimidazo[1,2-a]pyridine 
• 474012-78-7 ¹²⁵I-6-iodo-2-(4′-dimethylamino)phenyl-imidazo[1,2-a]-pyridine 
• 474012-75-4 4-(6-iodo-imidazo[1,2-a]pyridin-2-yl)-N,N-dimethylbenzenamine 

Relevant academic research and scientific papers

Structure-activity relationship of imidazo[1,2-a]pyridines as ligands for detecting β-amyloid plaques in the brain

A series of novel β-amyloid (Aβ) aggregate-specific ligands, 2-(4′-dimethylaminophenyl)-6-iodoimidazo[1,2-a]pyridine, 16(IMPY), and its related derivatives were prepared. An in vitro binding study with preformed Aβ aggregates showed that 16(IMPY) and its

BETA-AMYLOID PET IMAGING AGENTS

Novel derivatives of imidazopyridinylbenzeneamines and novel derivatives of benzothiazolylbenzeneamines are disclosed that offer improved behavior when used as imaging agents for positron emission tomography of beta-amyloids. Also disclosed is a palladium-catalyzed reaction scheme under microwave conditions for aryl thioethers in general that provides a high ratio of substitution relative to reduction and can be used for the imidazopyridinylbenzeneamine derivatives as well as other compounds of related structure.

Amyloid plaque aggregation inhibitors and diagnostic imaging agents

This invention relates to a method of imaging amyloid deposits and to labeled compounds, and methods of making labeled compounds useful in imaging amyloid deposits. This invention also relates to compounds, and methods of making compounds for inhibiting t