474088-35-2Relevant academic research and scientific papers
A simple and efficient asymmetric synthesis of 3-alkyl-isoindolin-1-ones
Pérard-Viret, Jo?lle,Prangé, Thierry,Tomas, Alain,Royer, Jacques
, p. 5103 - 5108 (2002)
A simple asymmetric access to 3-alkyl-isoindolin-1-ones was investigated through the diastereoselective alkylation of 2-[(1R)-2-hydroxy-1-phenylethyl]-2,3-dihydro-1H-isoindolin-1-one 5. High diastereoselectivities were observed with LDA or LiHMDS while the isolated yields were modest (about 50%). In contrast the use of NaHMDS gave good isolated yields (up to 85%) but lowered diastereoselectivities. This methodology offers an efficient asymmetric synthesis of 3-alkylated isoindolin-1-ones.
