2-[(1R)-2-hydroxy-1-phenylethyl]-2,3-dihydro-1H-isoindol-1-one

Base Information

• Chemical Name: 2-[(1R)-2-hydroxy-1-phenylethyl]-2,3-dihydro-1H-isoindol-1-one
• CAS No.: 474088-35-2
• Molecular Formula: C₁₆H₁₅NO₂
• Molecular Weight: 253.301
• Mol file: 474088-35-2.mol

Synonyms:2-[(1R)-2-hydroxy-1-phenylethyl]-2,3-dihydro-1H-isoindol-1-one

Chemical Property of 2-[(1R)-2-hydroxy-1-phenylethyl]-2,3-dihydro-1H-isoindol-1-one

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 2-[(1R)-2-hydroxy-1-phenylethyl]-2,3-dihydro-1H-isoindol-1-one

There total 1 articles about 2-[(1R)-2-hydroxy-1-phenylethyl]-2,3-dihydro-1H-isoindol-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

D-2-phenylglycinol (56613-80-0) + o-phthalic dicarboxaldehyde (643-79-8) → 2-[(1R)-2-hydroxy-1-phenylethyl]-2,3-dihydro-1H-isoindol-1-one (474088-35-2)

Guidance literature:

With hydrogenchloride; In isopropyl alcohol; at 20 ℃; for 4h;

DOI:10.1016/S0040-4020(02)00462-3

Reference yield: 72.0%

propyl bromide (106-94-5) + 2-[(1R)-2-hydroxy-1-phenylethyl]-2,3-dihydro-1H-isoindol-1-one (474088-35-2) → (3R)-propyl-2-[(1R)-2-hydroxy-1-phenylethyl]-2,3-dihydro-1H-isoindol-1-one + (3S)-propyl-2-[(1R)-2-hydroxy-1-phenylethyl]-2,3-dihydro-1H-isoindol-1-one

Guidance literature:

2-[(1R)-2-hydroxy-1-phenylethyl]-2,3-dihydro-1H-isoindol-1-one; With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.333333h;

propyl bromide; In tetrahydrofuran; at -78 ℃; for 2h;

DOI:10.1016/S0040-4020(02)00462-3

Reference yield: 65.0%

tert-butyl alcohol (75-65-0) + 2-[(1R)-2-hydroxy-1-phenylethyl]-2,3-dihydro-1H-isoindol-1-one (474088-35-2) → 2-[(1R)-2-t-butoxy-1-phenylethyl]-2,3-dihydro-1H-isoindol-1-one (474088-38-5)

Guidance literature:

With sulfuric acid; magnesium sulfate; In dichloromethane; at 20 ℃; for 96h;

DOI:10.1016/S0040-4020(02)00462-3

upstream raw materials:

D-2-phenylglycinol

o-phthalic dicarboxaldehyde

Downstream raw materials:

(3R)-3-Allyl-2-[(1R)-2-hydroxy-1-phenylethyl]-2,3-dihydro-1H-isoindol-1-one

2-[(1R)-2-t-butoxy-1-phenylethyl]-2,3-dihydro-1H-isoindol-1-one

(3R)-3-methyl-2-[(1R)-2-hydroxy-1-phenylethyl]-2,3-dihydro-1H-isoindol-1-one