474123-46-1Relevant academic research and scientific papers
Sequencing hydroxyethylamine-containing peptides via Edman degradation
Brewer, Matthias,Oost, Thorsten,Sukonpan, Chanokporn,Pereckas, Michael,Rich, Daniel H.
, p. 3469 - 3472 (2002)
(matrix presented) Hydroxyethylamine-containing peptides can be sequenced by automated Edman degradation to provide sequence information for peptide segments on either side of the peptide backbone modification.
1,2,3-Triazoles as amide bond mimics: Triazole scan yields protease-resistant peptidomimetics for tumor targeting
Valverde, Ibai E.,Bauman, Andreas,Kluba, Christiane A.,Vomstein, Sandra,Walter, Martin A.,Mindt, Thomas L.
supporting information, p. 8957 - 8960 (2013/09/02)
The triazole makes the difference: Replacement of amide bonds in the backbone of peptides by 1,4-disubstituted 1,2,3-triazole isosteres affords peptidomimetics with retained receptor affinity and cell-internalization properties, enhanced proteolytic stability, and improved tumor-targeting capabilities. Copyright
Solid-phase synthesis of peptide vinyl sulfones as potential inhibitors and activity-based probes of cysteine proteases
Wang, Gang,Mahesh, Uttamchandani,Chen, Grace Y. J.,Yao, Shao Q.
, p. 737 - 740 (2007/10/03)
(Matrix presented) Peptide vinyl sulfones were prepared from 2-chlorotrityl resin-bound phenolic amino vinyl sulfones in high yield and purity. This method enables the convenient synthesis of peptide vinyl sulfones having different amino acids at the Psu
Combinatorial Synthesis of a Small-Molecule Library Based on the Vinyl Sulfone Scaffold
Wang, Gang,Yao, Shao Q.
, p. 4437 - 4440 (2007/10/03)
(Equation presented) A 30-member library of small molecules based on the vinyl sulfone scaffold was prepared on rink amide resin, using solid phase-based reactions such as oxidation and Horner-Wadsworth-Emmons reaction. The library was designed such that
