474329-65-2Relevant academic research and scientific papers
Synthesis and biological evaluation of piperazine-based derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1)
Ye, Bin,Chou, Yuo-Ling,Karanjawala, Rushad,Lee, Wheeseong,Lu, Shou-Fu,Shaw, Kenneth J.,Jones, Steven,Lentz, Dao,Liang, Amy,Tseng, Jih-Lie,Wu, Qingyu,Zhao, Zuchun
, p. 761 - 765 (2004)
Compound 2 was identified by high throughput screening as a novel PAI-1 inhibitor. Systematic optimization of the A, B, and C segments of 2 resulted in the identification of a more potent compound 39 with good oral bioavailability. The synthesis and SAR d
