474385-91-6Relevant academic research and scientific papers
C(2)-symmetric Sc(III)-complexes as chiral Lewis acids. Catalytic enantioselective aldol additions to glyoxylate esters.
Evans, David A,Masse, Craig E,Wu, Jimmy
, p. 3375 - 3378 (2002)
Cationic Lewis acid complexes [Sc(pyridyl-bis(oxazolinyl)](Cl(2))SbF(6) 1a and 1b catalyze aldol reactions with ethyl glyoxylate with enantioselectivities ranging from 90 to 99% ee and syn reaction diastereoselections ranging from 90:10 to 95:5. [reaction: see text]
A general method for the enantioselective synthesis of pantolactone derivatives
Evans, David A.,Wu, Jimmy,Masse, Craig E.,MacMillan, David W. C.
, p. 3379 - 3382 (2007/10/03)
(matrix presented) An efficient enantioselective synthesis of β,β-dialkyl-γ-substituted pantolactones has been achieved utilizing the cationic [Sc((S,S)-R-pybox)]-(Cl)2+, R = Ph (9), t-Bu (10), complex in a catalyzed aldol reaction as the key step. The pantolactone derivatives are isolated in enantiomeric excesses.
