4744-60-9

Upstream product

• 929047-73-4 hexahydro-2H-pyrazino[1,2-a]pyrazin-1(6H)-one 
• 72351-59-8 ethyl 1,4-dibenzylpiperazin-2-carboxylate 
• 134749-46-5 1-benzyl-2-ethoxycarbonyl-4-(trifluoromethylsulfonyl)piperazine 
• 134749-48-7 1-bromoacetyl-2-ethoxycarbonyl-4-(trifluoromethylsulfonyl)-piperazine 
• 134749-49-8 8-(trifluoromethylsulfonyl)octahydropyrazino<1,2-a>pyrazine-1,4-dione 
• 134749-47-6 2-ethoxycarbonyl-4-(trifluoromethylsulfonyl)piperazine 
• 134749-45-4 ethyl 1-benzylpiperazine-2-carboxylate 

Downstream Products

• 929047-74-5 2-[3,5-bis(trifluoromethyl)phenyl]-N-[4-(4-fluoro-2-methylphenyl)-6-(octahydro-2H-pyrazino[1,2-a]pyrazin-2-yl)-3-pyridinyl]-N,2-dimethylpropanamide 

Relevant academic research and scientific papers

PYRIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF PSYCHOTIC DISORDERS

There are provided according to the invention novel compounds of formula (I) or a pharmaceutically acceptable salt thereof: (I) wherein: X represents a nitrogen atom; Y represents -C(H2)-, (-C(H2)-)2, -S(O2)- or -C(=O)-; Z represents -C(H2)-, -S(O2)-, -N(Rz)-, or an oxygen or sulphur atom; A represents hydrogen or -CH2OH; Rz represents hydrogen, C1-6 alkyl, C1-6 alkoxy, -COR7 or -SO2R7; R1 represents halogen, C1-6 alkyl, C1-6 alkoxy, =O, haloC1-6 alkyl, haloC1-6 alkoxy, hydroxyl or -CH2OH; m represents an integer from 0 to 3; R2 represents halogen, =O, C1-6alkyl (optionally substituted by one or more hydroxyl groups), -COOR7, -CONR7R8, C1-6 alkoxy, haloC1-6 alkyl, haloC1-6alkoxy or C1-6 alkyloC1-6 alkyl; n represents an integer from 0 to 3; p and q independently represent an integer from 0 to 2; R3 represents an -aryl, -heteroaryl, -heterocyclyl, -aryl-aryl, -aryl-heteroaryl, -aryl-heterocyclyl, -heteroaryl-aryl, -heteroaryl-heteroaryl, -heteroaryl-heterocyclyl, -heterocyclyl-aryl, -heterocyclyl-heteroaryl or -heterocyclyl-heterocyclyl group, all of which may be optionally substituted by one or more (e.g. 1, 2 or 3) halogen, C1-6 alkyl (optionally substituted by one or more hydroxyl groups), C3-8cycloalkyl, C1-6 alkoxy, hydroxyl, haloC1-6alkyl, haloC1-6 alkoxy, cyano, -S-C1-6 alkyl, -SO-C1-6 alkyl, -SO2-C1-6 alkyl, -COR7, -CONR7R8, -NR7R8, -NR7COC1-6 alkyl, -NR7SO2-C1-6alkyl, C1-6 alkyl-NR7R8, -OCONR7R8 , -NR7CO2R8 or -SO2NR7R8 groups; R4 and R5 independently represent C1-6 alkyl, or R4 and R5 together with the carbon atom to which they are attached may together form a C3-8cycloalkyl group; R6 represents halogen, C1-6 alkyl, C3-8cycloalkyl, C1-6 alkoxy, haloC1-6 alkyl or haloC1-6 alkoxy; s represents an integer from 0 to 4; R7 and R8 independently represent hydrogen, C1-6 alkyl or C3-8cycloalkyl; or solvates thereof.

A convenient synthesis of parent and 2-substituted octahydro-2H-pyrazino[1,2-a]-pyrazines

A series of octahydro-2H-pyrazino[1,2-a]pyrazines (1,4,8-triazabicyclo[4.4.0]decanes), 7 have been prepared by a new and efficient method starting from 1,4-dibenzyl-2-ethoxycarbonylpiperazine (1). The target compounds are precursors of a new series of ant