474432-56-9

Usage

Uses

Used in Pharmaceutical Industry:
Methyl 5-(hydroxymethyl)pyrazolo[1,5-a]pyridine-3-carboxylate is used as a key intermediate in the synthesis of various pharmaceuticals and bioactive compounds due to its heterocyclic ring system and potential biological activities.
Used in Drug Development:
Methyl 5-(hydroxymethyl)pyrazolo[1,5-a]pyridine-3-carboxylate is used as a building block in the development of novel drugs and therapeutic agents, particularly for conditions such as cancer, inflammation, and viral infections, owing to its demonstrated anticancer, anti-inflammatory, and antiviral properties.

Upstream product

• 922-67-8 propynoic acid methyl ester 
• 876379-84-9 N-amino-(4-hydroxymethyl)pyridinium-2,4-dinitrophenolate 
• 1313726-19-0 methyl 5-((tert-butyldimethylsilyloxy)methyl)pyrazolo[1,5-a]pyridine-3-carboxylate 
• 1313726-18-9 1-amino-4-((tert-butyldimethylsilyloxy)methyl)pyridinium 2,4-dinitrophenolate 
• 117423-41-3 4-((tert-butyldimethylsilyloxy)methyl)pyridine 
• 586-95-8 pyridine-4-methanol 

Downstream Products

• 1313727-03-5 pyrazolo[1,5-a]pyridin-5-ylmethanamine 
• 1313723-47-5 6-(4-fluorophenyl)-1-(pyrazolo[1,5-a]pyridin-5-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazine 
• 1355460-55-7 5,5'-(2,5,8,11,14-pentaoxapentadecane-1,15-diyl)bis[N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]pyrazolo[1,5-a]pyridine-3-carboxamide] 
• 1355460-54-6 5,5'-(2,5,8,11,14-pentaoxapentadecane-1,15-diyl)bis[N-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propyl]pyrazolo[1,5-a]pyridine-3-carboxamide] 
• 1355460-41-1 5-(2-ethoxyethoxymethyl)-N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]pyrazolo[1,5-a]pyridine-3-carboxamide 
• 1355460-40-0 5-(2-ethoxyethoxymethyl)-N-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propyl]pyrazolo[1,5-a]pyridine-3-carboxamide 
• 936637-97-7 methyl 5-formylpyrazolo[1,5-a]pyridine-3-carboxylate 
• 104468-87-3 pyrazolo [1,5-a]pyridine-5-carboxylic acid 
• 474432-59-2 pyrazolo[1,5-a]pyridine-5-carbaldehyde 

Relevant academic research and scientific papers

SPIRO-OXADIAZOLINE COMPOUNDS AS AGONISTS OF α-7-NICOTINIC ACETYLCHOLINE RECEPTORS

The present invention relates to novel spiro-oxadiazoline compounds that are suitable as agonists or partial agonists of a7-nAChR, and pharmaceutical compositions of the same, methods of preparing these compounds and compositions, and the use of these compounds and compositions in methods of maintaining, treating and/or improving cognitive function. In particular, methods of administering a spiro-oxadiazoline cx7-nAChR agonist or partial agonist, to a patient in need thereof, for example a patient with a cognitive deficiency and/or a desire to enhance cognitive function, that may derive a benefit therefrom.

Discovery of (S)-1-(1-(Imidazo[1,2- a ]pyridin-6-yl)ethyl)-6-(1-methyl-1 H -pyrazol-4-yl)-1 H -[1,2,3]triazolo[4,5- b ]pyrazine (Volitinib) as a Highly Potent and Selective Mesenchymal-Epithelial Transition Factor (c-Met) Inhibitor in Clinical Development for Treatment of Cancer

HGF/c-Met signaling has been implicated in human cancers. Herein we describe the invention of a series of novel triazolopyrazine c-Met inhibitors. The structure-activity relationship of these compounds was investigated, leading to the identification of compound 28, which demonstrated favorable pharmacokinetic properties in mice and good antitumor activities in the human glioma xenograft model in athymic nude mice.

CERTAIN TRIAZOLOPYRIDINES AND TRIAZOLOPYRAZINES, COMPOSITIONS THEREOF AND METHODS OF USE THEREFOR

Provided are certain triazolopyridines and triazolopyrazines, compositions thereof and methods of use therefor.

CERTAIN TRIAZOLOPYRIDINES AND TRIAZOLOPYRAZINES, COMPOSITIONS THEREOF AND METHODS OF USE THEREFOR

Provided are certain triazolopyridines and triazolopyrazines, compositions thereof and methods of use therefor.

Indolizines and aza-analog derivatives thereof as CNS active compounds

Presently disclosed are indolicine-based compounds of the general formula which have medical utility, for example as antipsychotics.

INDOLIZINE CARBOXAMIDES AND THE AZA AND DIAZA DERIVATIVES THEREOF

The invention relates to neuroreceptor-active carboxamide-substituted indolizine derivatives of general formula (I) wherein X represents a group of general formula (X1).

Interactive SAR studies: Rational discovery of super-potent and highly selective dopamine D3 receptor antagonists and partial agonists

Starting from dopamine receptor ligand BP897, an interactive drug discovery process leading to heterocyclic bioisosteres is demonstrated. The four step strategy involved a careful optimization of geometric and electronic properties by systematic modificat