methyl 5-(hydroxymethyl)pyrazolo[1,5-a]pyridine-3-carboxylate

Base Information

• Chemical Name: methyl 5-(hydroxymethyl)pyrazolo[1,5-a]pyridine-3-carboxylate
• CAS No.: 474432-56-9
• Molecular Formula: C₁₀H₁₀N₂O₃
• Molecular Weight: 206.201
• Mol file: 474432-56-9.mol

Synonyms:methyl 5-hydroxymethylpyrazolo[1,5-a]pyridine-3-carboxylate;5-Hydroxymethyl-pyrazolo[1,5-a]pyridine-3-carboxylic acid methyl ester;methyl 5-hydroxymethylpyrazolo[1,5-a]pyridin-3-carboxylate;

Chemical Property of methyl 5-(hydroxymethyl)pyrazolo[1,5-a]pyridine-3-carboxylate

Chemical Property:

• Melting Point: 105 °C
• PKA: 12.95±0.10(Predicted)
• PSA: 63.83000
• Density: 1.35±0.1 g/cm3(Predicted)
• LogP: 0.61320
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

Methyl5-(hydroxymethyl)pyrazolo[1,5-a]pyridine-3-carboxylate 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 5-(hydroxymethyl)pyrazolo[1,5-a]pyridine-3-carboxylate

There total 9 articles about methyl 5-(hydroxymethyl)pyrazolo[1,5-a]pyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

N-amino-(4-hydroxymethyl)pyridinium-2,4-dinitrophenolate (876379-84-9) + propynoic acid methyl ester (922-67-8) → methyl 5-(hydroxymethyl)pyrazolo[1,5-a]pyridine-3-carboxylate (474432-56-9)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 20h;

Reference yield: 32.0%

→ methyl 5-(hydroxymethyl)pyrazolo[1,5-a]pyridine-3-carboxylate (474432-56-9)

Guidance literature:

Reference yield: 27.0%

1-amino-4-(hydroxymethyl)pyridinium 2,4,6-trimethylbenzenesulfonate + propynoic acid methyl ester (922-67-8) → methyl 5-(hydroxymethyl)pyrazolo[1,5-a]pyridine-3-carboxylate (474432-56-9)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 18h; Inert atmosphere;

upstream raw materials:

propynoic acid methyl ester

N-amino-(4-hydroxymethyl)pyridinium-2,4-dinitrophenolate

pyridine-4-methanol

4-((tert-butyldimethylsilyloxy)methyl)pyridine

Downstream raw materials:

pyrazolo[1,5-a]pyridin-5-ylmethanamine

6-(4-fluorophenyl)-1-(pyrazolo[1,5-a]pyridin-5-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazine

5,5'-(2,5,8,11,14-pentaoxapentadecane-1,15-diyl)bis[N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]pyrazolo[1,5-a]pyridine-3-carboxamide]

5,5'-(2,5,8,11,14-pentaoxapentadecane-1,15-diyl)bis[N-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propyl]pyrazolo[1,5-a]pyridine-3-carboxamide]