474433-66-4Relevant academic research and scientific papers
Synthesis and antimicrobial evaluation of oxazole-1,4-naphthquinones
De Oliveira, Claudia G. T.,Ferreira, Vitor F.,Freitas, Cicero,Carballido, Jupira M.
, p. 199 - 204 (2007/10/03)
Several routes for preparing oxazole nucleus fused to 1,4-naphthoquinone moiety were studied. Three new oxazole-1,4-naphthoquinone derivatives (4a-c) were prepared and evaluated against phatogenic bacteria. The use of ortho-ester methodology was found to be the best synthetic method for preparing these oxazoles, which showed very low antibacterial activity. The intermediate 2 showed a broad spectrum of activity comparable with oxacillin and vancomycin.
