474452-42-1

Upstream product

• 10113-39-0 N-formyl-2-iodoaniline 
• 474452-37-4 4-[8-(p-toluenesulfonyl)-7-octynyl]-1,2-(methylenedioxy)benzene 
• 2635-13-4 1,2-(methylenedioxy)-4-bromobenzene 
• 474452-38-5 5-(6-chlorohexyl)benzo[d][1,3]dioxole 
• 356519-62-5 4-(7-octynyl)-1,2-(methylenedioxy)benzene 

Downstream Products

• 514805-35-7 2-(6-benzo[1,3]dioxol-5-yl-hexylidene)-4-oxo-3-(toluene-4-sulfonyl)-3,4-dihydro-2H-quinoline-1-carbaldehyde 
• 474452-40-9 2-{[(E)-7-Benzo[1,3]dioxol-5-yl-1-(toluene-4-sulfonylmethyl)-hept-1-enyl]-formyl-amino}-benzoic acid methyl ester 

Relevant academic research and scientific papers

Conjugate additions of o-iodoanilines and methyl anthranilates to acetylenic sulfones. A new route to quinolones including first syntheses of two alkaloids from the medicinal herb Ruta chalepensis

A novel synthesis of 2-substituted 4-quinolones was developed on the basis of the conjugate additions of appropriately ortho-substituted anilines to acetylenic sulfones followed by intramolecular acylation of the corresponding sulfone-stabilized anions. C

First syntheses of two quinoline alkaloids from the medicinal herb Ruta chalepensis via cyclization of an o-iodoaniline with an acetylenic sulfone

The first syntheses of two quinoline alkaloids found in the medicinal herb Ruta chalepensis are reported via the conjugate addition of an o-iodoaniline to an acetylenic sulfone, followed by Pd-catalyzed carbonylation, intra-molecular acylation of the core