4745-55-5Relevant academic research and scientific papers
Synthetic process for oxycamphor
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Paragraph 0034; 0038; 0039; 0043; 0044; 0048, (2019/12/25)
The invention discloses a synthetic process for oxycamphor. The synthetic process comprises the following steps: subjecting (+)-3,9-dibromocamphor and ethyl acetate to ester formation under the catalysis of 1,8-diazabicyclo[5.4.0]undec-7-ene, then carrying out reduction to obtain 9-acetoxycamphor, adding sodium hydroxide and N, N-dimethylformamide, carrying out a hydrolysis reaction to obtain (+)-9-hydroxycamphor, reducing 9-hydroxycamphor with lithium aluminum hydride in a tetrahydrofuran solution to obtain oxycamphor, performing concentration, and carrying out dissolving and decolorizing with dichloromethane to obtain the target oxycamphor. The method is high in yield and friendly to environment, and the purity of the obtained target oxycamphor is larger than 99.5%, which reaches currentnational injection standards in China.
Synthesis, structure and chiroptical spectra of the bicyclic α-diketones, imides and dithioimides related to santenone
Polonski, Tadeusz,Milewska, Maria J.,Gdaniec, Maria
, p. 3113 - 3122 (2007/10/03)
Isomeric α-diketones, imides and dithioimides related to santenone were prepared in a multistep synthesis from (+)-camphor and their CD spectra compared with those of analogous chromophoric systems related to camphor. In the case of conformationally rigid α-diketones the methyl substituents at C-7, lying on the symmetry plane of the chromophore, exert only a weak contribution to the n-π* Cotton effects. In contrast, the Cotton effect magnitudes of the anhydrides, imides and dithioimides are significantly affected by the substituents at C-8. The steric interaction of these chromophores with the syn-methyl group at C-8, leading to the chromophore distortion, was confirmed by X-ray crystallographic studies. Copyright (C) 2000 Elsevier Science Ltd.
