474511-91-6

Upstream product

• 49844-90-8 4-Chloro-2-methylthiopyrimidine 
• 766-98-3 1-ethynyl-4-fluorobenzene 
• 1122-74-3 4-iodo-2-(methylthio)pyrimidine 

Downstream Products

• 1161076-99-8 2-(4-fluorophenyl)-4,5-dihydro-3-[2-(methylthio)-4-pyrimidinyl]-7H-pyrazolo[1,5-c][1,3]oxazine 
• 1161076-14-7 4-[2-(4-fluorophenyl)-4,5-dihydro-7H-pyrazolo[1,5-c][1,3]oxazin-3-yl]-N-(1-methylethyl)-2-pyrimidinamine 
• 1161076-78-3 2-(4-fluorophenyl)-4,5-dihydro-3-[2-(methylsulfonyl)-4-pyrimidinyl]-7H-pyrazolo[1,5-c][1,3]oxazine 
• 1161076-37-4 N-cyclopropyl-4-[2-(4-fluorophenyl)-4,5,6,7-tetrahydro-7-methylpyrazolo[1,5-b]pyridazin-3-yl]-2-pyrimidinamine 
• 1161076-95-4 3-(2-chloro-4-pyrimidinyl)-2-(4-fluorophenyl)-4,5,6,7-tetrahydro-7-methylpyrazolo[1,5-b]pyridazine 
• 1161076-47-6 3-(2-chloro-4-pyrimidinyl)-2-(4-fluorophenyl)-4,5,6,7-tetrahydropyrazolo[1,5-b]pyridazine 
• 1161076-34-1 2-[[4-[2-(4-fluorophenyl)-4,5,6,7-tetrahydropyrazolo[1,5-b]pyridazin-3-yl]-2-pyrimidinyl]amino]-1-propanol 
• 1161076-94-3 phenylmethyl 2-(4-fluorophenyl)-5,6-dihydro-3-[2-[(2-hydroxy-1-methylethyl)amino]-4-pyrimidinyl]pyrazolo[1,5-b]pyridazine-7(4H)-carboxylate 
• 1161076-36-3 1-[3-[2-(cyclopropylamino)-4-pyrimidinyl]-2-(4-fluorophenyl)-5,6-dihydropyrazolo[1,5-b]pyridazin-7(4H)-yl]ethanone 
• 1161076-33-0 N-cyclopropyl-4-[2-(4-fluorophenyl)-4,5,6,7-tetrahydropyrazolo[1,5-b]pyridazin-3-yl]-2-pyrimidinamine 
• 1161076-93-2 phenylmethyl 3-[2-(cyclopropylamino)-4-pyrimidinyl]-2-(4-fluorophenyl)-5,6-dihydropyrazolo[1,5-b]pyridazine-7(4H)-carboxylate 
• 1161076-46-5 phenylmethyl 3-(2-chloro-4-pyrimidinyl)-2-(4-fluorophenyl)-5,6-dihydropyrazolo[1,5-b]pyridazine-7(4H)-carboxylate 
• 1161075-25-7 N-(cyclopropylmethyl)-4-[2-(4-fluorophenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-3-yl]-2-pyrimidinamine 
• 1161076-74-9 2-(4-fluorophenyl)-4,5,6,7-tetrahydro-3-[2-(methylsulfonyl)-4-pyrimidinyl]pyrazolo[1,5-a]pyridine 

Relevant academic research and scientific papers

FUNGICIDAL BICYCLIC PYRAZOLES

Disclosed are compounds of Formulae 1 and 1a, N-oxides, and salts thereof, wherein R1, R1a, Y, and J are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling

Pyrazolopyridine antiherpetics: SAR of C2′ and C7 amine substituents

A novel series of potent pyrazolo[1,5-a]pyridine inhibitors of herpes simplex virus 1 replication have been identified. Several complimentary synthetic methods were developed to allow facile access to a diverse set of analogs from common late stage interm

Triazole compounds useful in treating diseases associated with unwanted cytokine activity

The present invention relates to 4-aryl triazoles having the formula: wherein R1 is independently selected from the group consisting of: lower alkyl, lower alkenyl, lower alkynyl, lower heteroalkyl, lower heteroalkenyl, lower heteroalkynyl, heterocycloalkyl, heteroaryl, halo, CN, OR4, SR4, S(O)R4, S(O)2R4, and NR4R5; and Q is has the general formula: said compounds are useful in treating diseases associated with unwanted cytokine activity, inter alia, interleukin-1 (IL-1) and tumor necrosis factor (TNF) from cells.