474538-99-3

Basic information

• Product Name: 1'-benzylspiro[indoline-3,4'-piperidine]
• Synonyms: 1'-benzylspiro[indoline-3,4'-piperidine];1,2-dihydro-1'-(phenylmethyl)-Spiro[3H-indole-3,4'-piperidine];1'-benzyl-1,2-dihydrospiro[indole-3,4'-piperidine];1'-benzylspiro[1,2-dihydroindole-3,4'-piperidine]
• CAS NO: 474538-99-3
• Molecular Formula: C₁₉H₂₂N₂
• Molecular Weight: 278.397
• Mol File: 474538-99-3.mol

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1'-benzylspiro[indoline-3,4'-piperidine](CAS DataBase Reference)
• NIST Chemistry Reference: 1'-benzylspiro[indoline-3,4'-piperidine](474538-99-3)
• EPA Substance Registry System: 1'-benzylspiro[indoline-3,4'-piperidine](474538-99-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 474538-99-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
1'-Benzylspiro[indoline-3,4'-piperidine] is used as a key intermediate in the synthesis of various pharmaceuticals and biologically active molecules due to its distinctive structural features.
Used in Anti-Inflammatory Applications:
1'-Benzylspiro[indoline-3,4'-piperidine] is used as an anti-inflammatory agent, leveraging its potential to modulate inflammatory pathways and alleviate symptoms associated with inflammation.
Used in Analgesic Applications:
As an analgesic, 1'-benzylspiro[indoline-3,4'-piperidine] is utilized for its pain-relieving properties, offering a potential alternative for the management of acute and chronic pain conditions.
Used in Anti-Tumor Applications:
In the field of oncology, 1'-benzylspiro[indoline-3,4'-piperidine] is used as an anti-tumor agent, with studies indicating its potential to inhibit tumor growth and progression.
Used in Central Nervous System Drug Development:
1'-Benzylspiro[indoline-3,4'-piperidine] is used as a dopaminergic and serotoninergic ligand, making it a promising candidate for the development of new drugs targeting the central nervous system, particularly for conditions related to neurotransmitter imbalances.
Used in Research and Development:
Due to its diverse range of pharmacological activities, 1'-benzylspiro[indoline-3,4'-piperidine] is extensively used in research and development for further exploration of its potential applications in medicine and pharmacology.

Upstream product

• 22065-85-6 N-benzyl-4-formylpiperidine 
• 100-63-0 phenylhydrazine 

Downstream Products

• 867009-74-3 C₂₄H₃₀N₂O₂ 

Relevant articles and documents

SUBSTITUTED DIAZA-SPIRO-[4.5]-DECANE DERIVATIVES AND THEIR USE AS NEUROKININ ANTAGONISTS

This invention concerns substituted diaza-spiro-[4.5]-decane derivatives having neurokinin antagonistic activity, in particular NK1 antagonistic activity, a combined NK1/NK2 antagonist ic activity, a combined NK1/NK3 antagonist ic activity and a combined NK1/NK2/NK3 antagonistic activity, their preparation, compositions comprising them and their use as a medicine, in particular for the treatment and/or prophylaxis of schizophrenia, emesis, anxiety and depression, irritable bowel syndrome (IBS), circadian rhythm disturbances, pre-eclampsia, nociception, pain, in particular visceral and neuropathic pain, pancreatitis, neurogenic inflammation, asthma, chronic obstructive pulmonary disease (COPD) and micturition disorders such as urinary incontinence. The compounds according to the invention can be represented by general Formula (I) and comprises also the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeric forms thereof, the N-oxide form thereof and prodrugs thereof, wherein all substituents are defined as in Claim 1.