474645-91-5

Basic information

• Product Name: (3R)-3-{[4-(trifluoromethyl)phenyl]amino}pentanenitrile
• Synonyms: (3R)-3-{[4-(Trifluoromethyl)phenyl]amino}pentanenitrile; pentanenitrile, 3-[[4-(trifluoromethyl)phenyl]amino]-, (3R)-
• CAS NO: 474645-91-5
• Molecular Formula: C₁₂H₁₃F₃N₂
• Molecular Weight: 242.2402
• EINECS: 610-351-7
• Mol File: 474645-91-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 345.695°C at 760 mmHg
• Flash Point: 162.871°C
• Density: 1.198g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.498
• CAS DataBase Reference: (3R)-3-{[4-(trifluoromethyl)phenyl]amino}pentanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: (3R)-3-{[4-(trifluoromethyl)phenyl]amino}pentanenitrile(474645-91-5)
• EPA Substance Registry System: (3R)-3-{[4-(trifluoromethyl)phenyl]amino}pentanenitrile(474645-91-5)

Safety Data

• Hazardous Substances Data: 474645-91-5(Hazardous Substances Data)

Upstream product

• 98-56-6 4-chlorobenzotrifluoride 
• 400090-60-0 (R)-3-aminopentanenitrile 
• 198493-28-6 (R)-N-tert-butyloxycarbonyl-3-aminopentanenitrile 
• 474645-97-1 (R)-3-aminopentanenitrile methanesulfonic acid salt 
• 213697-53-1 DavePhos 
• 98-80-6 phenylboronic acid 

Downstream Products

• 474645-96-0 (2R,4S)-(2-ethyl-6-trifluoromethyl-1,2,3,4-tetrahydroquinolin-4-yl)carbamic acid benzyl ester 
• 874501-92-5 C₂₆H₂₄F₉N₃O₂ 
• 874502-03-1 C₃₀H₃₁F₉N₆O₂ 
• 874501-96-9 C₂₈H₂₆F₉N₇O₂ 
• 874502-50-8 C₂₉H₂₈F₉N₇O₂ 
• 874502-29-1 C₂₈H₂₈ClF₉N₆O₂ 
• 874502-23-5 C₂₈H₂₉F₉N₆O₃ 
• 874502-05-3 C₂₉H₂₉F₉N₆O₄ 
• 874502-32-6 C₂₈H₂₈F₉N₇O₃ 
• 874502-35-9 C₃₀H₃₂F₉N₇O₃ 
• 874502-26-8 C₂₉H₃₁F₉N₆O₃ 
• 874502-11-1 C₂₉H₃₁F₉N₆O₂ 
• 874502-20-2 C₃₀H₃₃F₉N₆O₂ 
• 874502-14-4 C₃₀H₃₃F₉N₆O₂ 

Relevant articles and documents

Design and synthesis of new tetrahydroquinolines derivatives as CETP inhibitors

This letter describes the discovery and SAR optimization of tetrazoyl tetrahydroquinoline derivatives as potent CETP inhibitors. Compound 6m exhibited robust HDL-c increase in hCETP/hApoA1 double transgenic model and favorable pharmacokinetic properties.

Intermediates of CETP inhibitors

This invention relates to intermediates useful in the preparation of CETP inhibitors and methods of preparation thereof.