474657-72-2

Basic information

• Product Name: 6-Bromo-2-(1,1-dimethyl-2-propenyl)-N-1H-indole-3-ethanaminehydrochloride
• Synonyms: 6-Bromo-2-(1,1-dimethyl-2-propenyl)-N-1H-indole-3-ethanaminehydrochloride;Desformylflustrabromine hydrochloride;1H-Indole-3-ethanaMine, 6-broMo-2-(1,1-diMethyl-2-propenyl)-N-Methyl-
• CAS NO: 474657-72-2
• Molecular Formula: C16H21BrN2.HCl
• Molecular Weight: 357.72
• Mol File: 474657-72-2.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: Store at +4°C
• CAS DataBase Reference: 6-Bromo-2-(1,1-dimethyl-2-propenyl)-N-1H-indole-3-ethanaminehydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Bromo-2-(1,1-dimethyl-2-propenyl)-N-1H-indole-3-ethanaminehydrochloride(474657-72-2)
• EPA Substance Registry System: 6-Bromo-2-(1,1-dimethyl-2-propenyl)-N-1H-indole-3-ethanaminehydrochloride(474657-72-2)

Safety Data

• Hazardous Substances Data: 474657-72-2(Hazardous Substances Data)

Usage

Uses

Desformylflustrabromine Hydrochloride is a positive allosteric modulator of α4β2 nicotinic acetylcholine receptors.

Upstream product

• 209169-05-1 N-Methyl-6-bromotryptamine 
• 209168-89-8 6-bromo-N₁₀-methyl-N₁₀-Boc-tryptamine 
• 52415-29-9 6-bromo-1H-indole 
• 1353012-45-9 C₂₂H₁₉BrCo₂N₂O₆ 
• 951322-09-1 tert-butyl 2-(6-bromo-2-(1,1-dimethylallyl)-1H-indol-3-yl)ethyl-N-methylcarbamate 
• 55454-18-7 9-(3-methylbut-2-enyl)-9-borabicyclo[3.3.1.]nonane 
• 54268-27-8 N^b-formyl-N^b-methyltryptamine 
• 598-25-4 Dimethylallene 
• 61-49-4 [2-(1H-indol-3-yl)-ethyl]-methylamine 
• 863885-34-1 N-{2-[2-(1,1-dimethylallyl)-1H-indol-3-yl]ethyl}-N-methylformamide 
• 80693-54-5 N-{2-[6-bromo-2-(2-methylbut-3-en-2-yl)-1H-indol-3-yl]ethyl}-N-methylformamide 

Relevant articles and documents

Total synthesis of flustramine C via dimethylallyl rearrangement

(Chemical Equation Presented) The marine natural product flustramine C from the bryozoan Flustra foliacea was synthesized in five steps and 38% yield starting from Nb-methyltryptamine. The key step is the biomimetic oxidation of the natural pro

Concise synthesis of deformylflustrabromine, a marine indole alkaloid, through a 2-propynyl dicobalt hexacarbonyl complex

Deformylflustrabromine, a marine indole alkaloid, was synthesized from 6-bromotryptamine, a plausible biosynthetic precursor, without protection of the amino group by a two-step reverse prenylation involving the Nicholas reaction and reductive decomplexat

Synthesis of desformylflustrabromine and its evaluation as an α4β2 and α7 nACh receptor modulator

Desformylflustrabromine (dFBr; 1) and desformylflustrabromine-B (dFBr-B; 2) have been previously isolated from natural sources, and the former has been demonstrated to be a novel and selective positive allosteric modulator of α4β2 nicotinic acetylcholine (nACh) receptors. The present study describes the synthesis of water-soluble salts of 1 and 2, and confirms and further investigates the actions of 1 and 2 using two-electrode voltage clamp recordings.