474686-33-4

Upstream product

• 956111-87-8 C₂₃H₃₃N₃O₇ 
• 2212-75-1 N₂-[(benzyloxy)carbonyl]-L-lysine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 474686-34-5 C₂₃H₃₅N₃O₈ 
• 2389-60-8 Z-Lys(Boc)-OH 
• 84860-21-9 (S)-2-((S)-2-Benzyloxycarbonylamino-6-tert-butoxycarbonylamino-hexanoylamino)-3-hydroxy-propionic acid methyl ester 

Downstream Products

• 474686-23-2 2-(1-benzyloxycarbonylamino-5-tert-butoxycarbonylamino-pentyl)-oxazole-4-carboxylic acid 
• 956111-91-4 C₂₉H₃₃N₅O₉ 
• 956111-89-0 C₂₉H₃₇N₅O₁₀ 
• 956111-88-9 C₃₈H₅₇N₅O₁₀Si 
• 1111629-64-1 C₂₉H₃₅N₅O₉ 
• 474686-25-4 2-(1-{[2-(1-benzyloxycarbonylamino-5-tert-butoxycarbonylamino-pentyl)-oxazole-4-carbonyl]-amino}-3-tert-butoxycarbonyl-propyl)-thiazole-4-carboxylic acid ethyl ester 
• 474686-46-9 2-(1-{[2-(1-benzyloxycarbonylamino-3-tert-butoxycarbonyl-propyl)-thiazole-4-carbonyl]-amino}-5-tert-butoxycarbonylamino-pentyl)-oxazole-4-carboxylic acid methyl ester 
• 474686-27-6 2-((4S,13S)-13-Benzyloxycarbonylamino-2,10-dioxo-15-thia-3,9,17-triaza-bicyclo[12.2.1]heptadeca-1⁽¹⁶⁾,14⁽¹⁷⁾-dien-4-yl)-oxazole-4-carboxylic acid 

Relevant academic research and scientific papers

Macrocyclic hexaoxazoles: Influence of aminoalkyl substituents on RNA and DNA G-quadruplex stabilization and cytotoxicity

A series of 24-membered macrocyclic hexaoxazoles containing one or two aminoalkyl substituents was synthesized and evaluated for cytotoxicity and for their ability to selectively stabilize G-quadruplex DNA and RNA. The most cytotoxic analog 4a, with IC50 values of 25 and 130 nM using KB3-1 and RPMI 8402 cells, is efficacious in vivo in athymic nude mice with a human tumor xenograft from the breast cancer cell line MDA-MB-435.

THERAPEUTIC COMPOUNDS

The invention provides compounds of formula I: wherein A, B, D, E, R1, R2, R3, R4, R5, X, and ----- have any values defined herein, as well as salts thereof. The compounds have activity as G-quadruplex DNA stabilizers and as anti-proliferative agents.

THERAPEUTIC COMPOUNDS

The invention provides compounds of formula (I) wherein A, B, R1, F, G, n, n' and the dotted line have any values defined herein, as well as salts thereof. The compounds have activity as anti-proliferative agents.

THERAPEUTIC COMPOUNDS

The invention provides compounds of formula I: wherein A, B, D, E, R1, R2, R3, R4, R5, X, and ----- have any values defined herein, as well as salts thereof. The compounds have activity as G-quadruplex DNA stabalizers and as anti-proliferative agents.

Regioselective synthesis of antiparallel loops on a macrocyclic scaffold constrained by oxazoles and thiazoles

(matrix presented) The regioselective syntheses and structures are reported for two tris-macrocylic compounds, each possessing two antiparallel loops on a macrocyclic scaffold constrained by two oxazoles and two thiazoles. NMR solution structures show the