474711-89-2

Usage

Uses

Used in Pharmaceutical Industry:
PIPERAZINE-1-CARBOXYLIC ACID AMIDE HCL is used as a key intermediate in the synthesis of heteroaromatic derivatives, specifically as phosphodiesterase 4 (PDE4) inhibitors. PDE4 inhibitors are a class of drugs that modulate the activity of the PDE4 enzyme, which plays a crucial role in various physiological processes, including inflammation and immune response. By inhibiting PDE4, these compounds can help regulate these processes and have potential therapeutic applications in treating conditions such as asthma, chronic obstructive pulmonary disease (COPD), and inflammatory disorders.
In the synthesis of PDE4 inhibitors, PIPERAZINE-1-CARBOXYLIC ACID AMIDE HCL serves as a crucial component, providing the necessary structural features for the development of these drugs. Its presence in the molecular structure allows for the formation of active compounds that can effectively bind to and inhibit the PDE4 enzyme, leading to the desired therapeutic effects.
Overall, PIPERAZINE-1-CARBOXYLIC ACID AMIDE HCL is a valuable compound in the pharmaceutical industry, playing a significant role in the development of PDE4 inhibitors and other related drugs. Its unique structure and properties make it an essential building block in the synthesis of these therapeutic agents, contributing to the advancement of treatments for various diseases and conditions.

InChI:InChI=1/C5H11N3O/c6-5(9)8-3-1-7-2-4-8/h7H,1-4H2,(H2,6,9)

Upstream product

• 883554-88-9 tert-butyl 4-carbamoylpiperazine-1-carboxylate 

Downstream Products

• 1400795-86-9 4-{4-[(3S)-2,3-dihydro[1,4]dioxino[2,3-b]pyridin-3-yl]benzyl}piperazine-1-carboxamide 

Relevant academic research and scientific papers

HETEROAROMATIC DERIVATIVES AND PHARMACEUTICAL APPLICATIONS THEREOF

Disclosed are heteroaryl derivatives, pharmaceutical composition and uses in the manufacture of a medicine for treating respiratory diseases, especially for chronic obstructive pulmonary disease (COPD).

Aromatic heterocyclic derivatives and applications of aromatic heterocyclic derivatives in medicines

The present invention discloses aromatic heterocyclic derivatives and applications of the aromatic heterocyclic derivatives in medicines, and specifically provides a class of aromatic heterocyclic compounds or stereoisomers, geometric isomers, tautomers, racemic bodies, nitrogen oxides, hydrates, solvates, metabolites, pharmaceutically acceptable salts or prodrugs thereof, and pharmaceutical compositions containing the compounds. The present invention further discloses uses of the compounds or pharmaceutical compositions in drug preparation, wherein the drug is used for treatment of respiratory diseases, particularly chronic obstructive pulmonary disease (COPD).

3- Or 4-monosubstituted phenol derivatives useful as H3 ligands

The invention relates to 3- or 4-monosubstituted phenol derivatives and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. Said 3- or 4-monosubstituted phenol derivatives are H3 ligands and are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.

Beta lactam compounds and their use as inhibitors of tryptase

Beta lactam compounds are provided which have the structure wherein B, A, D, R1, R2, R3 and X1 are as defined herein, and which are useful as inhibitors of tryptase, thrombin, trypsin, Factor Xa, Factor VIIa, and urokinase-type plasminogen activator and may be employed in preventing and/or treating asthma and allergic rhinitis.