474801-75-7

Upstream product

• 152120-54-2 N,N'-bis( tert-butoxycarbonyl)-1H-pyrazole-1-carboxamidine 
• 60-12-8 2-phenylethanol 
• 474801-43-9 (2S,4S,5S,6R)-5-Acetylamino-4-(tert-butyl-dimethyl-silanyloxy)-6-[(S)-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-phenethyloxy-methyl]-2-methoxy-tetrahydro-pyran-2-carboxylic acid methyl ester 
• 474801-60-0 (4S,5R,6R)-5-Acetylamino-4-azido-6-((1S,2R)-2,3-diacetoxy-1-phenethyloxy-propyl)-5,6-dihydro-4H-pyran-2-carboxylic acid methyl ester 
• 138337-18-5 bis(2-phenylethyl) sulfate 
• 24281-43-4 sulfurous acid diphenethyl ester 

Relevant academic research and scientific papers

Synthesis and anti-influenza virus activity of 7-O-alkylated derivatives related to zanamivir

A series of 7-alkyl ether derivatives related to zanamivir were synthesized using direct alkylation of the C-7 alcohol of sialic acid. Alkyl ether moiety of less than 12 carbons in length showed low nanomolar inhibitory activity against influenza A virus sialidase. Furthermore, their moiety improved influenza A virus plaque reduction activity compared to zanamivir. However, removal of the 8,9-diol of the 7-O-alkyl derivatives resulted in loss of antiviral potency. This result suggests that 8,9-diol must play an important role in binding with both influenza A and B virus sialidases.