4749-07-9

Upstream product

• 67-51-6 3,5-dimethyl-1H-pyrazole 
• 140-88-5 ethyl acrylate 
• 539-74-2 Ethyl 3-bromopropionate 
• 623-71-2 ethyl 3-chloropropanoate 

Downstream Products

• 1092551-88-6 3-{4-[(7-hydroxy-6-methylindan-4-yl)methyl]-3,5-dimethyl-1H-pyrazol-1-yl}propionic acid 
• 72145-01-8 3-(3,5-dimethyl-1H-pyrazol-1-yl)propanoic acid 

Relevant academic research and scientific papers

METHODS OF PRODUCING PYRAZOLE COMPOUNDS

The present invention is directed to methods of producing substituted pyrazole based compounds through novel intermediates and unique processes for preparing such intermediates which enables synthesis of final product through commercially viable route of synthesis. The present invention is also directed to novel methods of producing substituted pyrazole based thyroid like compounds, and solid forms of 3-{4-[(7-hydroxy-6-methyl-indan-4-yl)methyl]-3,5-dimethyl-1H-pyrazol-1-yl}-propanoic acid, its pharmaceutical compositions, and methods of preparation thereof.

REACTION DE SUBSTITUTION DE L'ACRYLATE D'ETHYLE PAR LE DIMETHYL 3,5-PYRAZOLE INDUITE PAR DES SELS DE CUIVRE

When copper salts are added to a mixture of 3,5-dimethylpyrazole and ethylacrylate, a substitution reaction between dimethylpyrazole and ethylacrylate is observed.