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Usage

Uses

Used in Pharmaceutical Industry:
6-Bromo-2-(methylthio)benzo[d]thiazole is used as a pharmaceutical intermediate for the development of new drugs. Its biological properties make it a promising candidate for the treatment of various diseases, including its potential as an inhibitor of the enzyme indoleamine 2,3-dioxygenase, which is involved in the immune response and has been linked to various diseases.
Used in Agrochemical Industry:
6-Bromo-2-(methylthio)benzo[d]thiazole is used as an active ingredient in agrochemicals due to its antimicrobial properties. It can be employed in the development of pesticides, fungicides, or herbicides to protect crops from various pathogens and pests, thereby increasing agricultural productivity.
Used in Organic Synthesis:
6-Bromo-2-(methylthio)benzo[d]thiazole serves as a building block in organic synthesis for the preparation of new chemical entities. Its unique structure allows for the creation of novel compounds with potential applications in various industries, such as pharmaceuticals, materials science, and agrochemicals.

Upstream product

• 51618-30-5 6-bromo-1,3-benzothiazole-2(3H)-thione 
• 77-78-1 dimethyl sulfate 
• 140-89-6 potassium ethyl xanthogenate 
• 74-88-4 methyl iodide 
• 615-57-6 2,4-dibromo-aniline 

Downstream Products

• 1112982-48-5 N-(2-chloro-5-(2-(methylsulfanyl)-1,3-benzothiazol-6-yl)-3-pyridinyl)-4-methoxybenzenesulfonamide 

Relevant academic research and scientific papers

Exploration of Benzothiazole Rhodacyanines as Allosteric Inhibitors of Protein-Protein Interactions with Heat Shock Protein 70 (Hsp70)

Cancer cells rely on the chaperone heat shock protein 70 (Hsp70) for survival and proliferation. Recently, benzothiazole rhodacyanines have been shown to bind an allosteric site on Hsp70, interrupting its binding to nucleotide-exchange factors (NEFs) and promoting cell death in breast cancer cell lines. However, proof-of-concept molecules, such as JG-98, have relatively modest potency (EC50 ≈ 0.7-0.4 μM) and are rapidly metabolized in animals. Here, we explored this chemical series through structure- and property-based design of ～300 analogs, showing that the most potent had >10-fold improved EC50 values (～0.05 to 0.03 μM) against two breast cancer cells. Biomarkers and whole genome CRISPRi screens confirmed members of the Hsp70 family as cellular targets. On the basis of these results, JG-231 was found to reduce tumor burden in an MDA-MB-231 xenograft model (4 mg/kg, ip). Together, these studies support the hypothesis that Hsp70 may be a promising target for anticancer therapeutics.

Palladium-Catalyzed Insertion of Isocyanides into the C?S Bonds of Heteroaryl Sulfides

Insertion of tert-butyl isocyanide into the C(sp2)?S bonds of heteroaryl sulfides is catalyzed by a palladium diphosphine complex. Thioimidates generated through this reaction could be readily hydrolyzed under acidic conditions to yield the corresponding thioesters, which are of synthetic use. This insertion is useful because starting heteroaryl sulfides were readily prepared by either conventional ways or through sulfur-specific extended Pummerer reactions.