615-57-6

Basic information

• Product Name: 2,4-Dibromoaniline
• Synonyms: 2,4-DIBROMOANILINE;2,4-DIBROMOBENZENAMINE;2,4-Dibromanilin;2,4-dibromo-benzenamin;2 4-DIBROMOANILINE 98% (GC);2,4-Dibromoaniline, 98+%;2,4-Dibromoaniline 98%
• CAS NO: 615-57-6
• Molecular Formula: C₆H₅Br₂N
• Molecular Weight: 250.92
• EINECS: 210-434-4
• Product Categories: Anilines, Amides & Amines;Bromine Compounds;Amines;C2 to C6;Nitrogen Compounds;Building Blocks;C6;Chemical Synthesis;Nitrogen Compounds;Organic Building Blocks
• Mol File: 615-57-6.mol
• Article Data: 51

Chemical Properties

• Melting Point: 78-82 °C
• Boiling Point: 156 °C (24 mmHg)
• Flash Point: 156°C/24mm
• Appearance: White crystal or powder
• Density: 2.26
• Vapor Pressure: 0.0095mmHg at 25°C
• Refractive Index: 1.5800 (estimate)
• Storage Temp.: Store below +30°C.
• PKA: 1.83±0.10(Predicted)
• Water Solubility: Insoluble in water
• BRN: 2206653
• CAS DataBase Reference: 2,4-Dibromoaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Dibromoaniline(615-57-6)
• EPA Substance Registry System: 2,4-Dibromoaniline(615-57-6)

Safety Data

• Hazard Codes: Xn,Xi,N,T
• Statements: 36/37/38-33-20/21/22-51/53-25
• Safety Statements: 36/37/39-26-61-45
• RIDADR: 2811
• WGK Germany: 3
• TSCA: T
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 615-57-6(Hazardous Substances Data)

Usage

Chemical Properties

beige powder

Uses

Different sources of media describe the Uses of 615-57-6 differently. You can refer to the following data:
1. 2,4-Dibromoaniline is used in preparation of glycopeptides and targeted bifunctional degraders.
2. 2,4-Dibromoaniline can be used as:A starting material to synthesize acetylenic amine by reacting with trimethylsilylacetylene, which is used as a ligand to prepare the bis-amido complex of Ti(IV).A substrate in the Pd-catalyzed ortho-selective cross-coupling reactions of dihaloarenes with Grignard reagents.A reactant to prepare dialkyl-substituted aminoaryl sulfides using a Grignard reagent.A starting material to synthesize substituted 2-mercapto benzimidazoles.

Purification Methods

Crystallise the aniline from aqueous EtOH. The picrate has m 124o. [Beilstein 12 H 655, 12 I 326, 12 II 356, 12 III 1471, 12 IV 1532.]

InChI:InChI=1/C6H5Br2N/c7-4-1-2-6(9)5(8)3-4/h1-3H,9H2

Upstream product

• 106-40-1 4-bromo-aniline 
• 6374-91-0 5,7-Dibromoisatin 
• 100-65-2 N-Phenylhydroxylamine 
• 2439-85-2 N-bromophthalimide 
• 62-53-3 aniline 
• 615-36-1 2-bromoaniline 
• 108-36-1 1,3-dibromobenzene 
• 482-89-3 1H,1H'-2,2'-Biindolylidene-3,3'-dione 
• 87-48-9 5-Bromo-1H-indole-2,3-dione 
• 91-56-5 indole-2,3-dione 
• 63911-87-5 N-(trimethylsilyl)-4-bromoaniline 
• 3768-55-6 N-trimethylsilylaniline 
• 64-17-5 ethanol 
• 7664-41-7 ammonia 

Downstream Products

• 147-82-0 2,4,6-tribromoaniline 
• 106-40-1 4-bromo-aniline 
• 23373-04-8 2',4'-dibromoacetanilide 
• 114233-35-1 N-(2,4-dibromo-phenyl)-malonamic acid 
• 733-00-6 bis-(2,4-dibromo-phenyl)-carbodiimide 
• 1196034-23-7 C₁₄H₁₅Br₂NO₃ 
• 1196034-16-8 2-(2,4-dibromophenylamino)-5,5-dimethyl-4-oxohex-2-enoic acid 
• 147542-38-9 N-(2,4-dibromophenyl)benzamide 
• 58140-22-0 C₁₄H₇Br₄N₅ 
• 23745-16-6 Cyclopropan-2,4-dibrom-carboxanilid 
• 16582-60-8 2-amino-4,6-dibromobenzo[d]thiazole 
• 418761-26-9 1,3-bis-(2,4-dibromo-phenyl)-triazene 
• 42016-96-6 salicylic acid-(2,4-dibromo-anilide) 
• 92160-22-0 N-(2,4-dibromo-phenyl)-N'-o-tolyl-thiourea 

Relevant articles and documents

NOVEL TRICYCLIC COMPOUND AS IRAK4 INHIBITOR

The present invention relates to a pharmaceutical composition for preventing or treating autoimmune diseases or tumors, containing, as an active ingredient, a tricyclic compound represented by the following Chemical Formula 1 or a pharmaceutically acceptable salt thereof, and a health food composition for preventing or alleviating autoimmune diseases or tumors, containing the tricyclic compound as an active ingredient. The tricyclic compound represented by Chemical Formula 1 of the present invention has an excellent inhibitory activity against IRAK4, and thus can be usefully used for the prevention, treatment, or alleviation of autoimmune diseases or tumors.

Selective Thiocyanation and Aromatic Amination to Achieve Organized Annulation of Enaminone with Thiocyanate

A tandem insertion of thiocyanate to enamine was performed for the regioselective synthesis of multisubstituted benzoimidazo[2,1-b]thiazoles. This method was shown to be effective in addressing the issue of isomerization encountered in common strategies. With a change made to the leading group on the aniline fragment of enamine, the reaction achieved different transformations, thus enabling multisubstituted benzo[4,5]imidazo[2,1-b]thiazoles and thiazoles in satisfactory yields.

Aryl halide and synthesis method and application thereof

The invention discloses a synthesis method of aryl halides (including aryl bromide shown as a formula (2) and aryl iodide shown as a formula (3)). All the systems are carried out in an air atmosphere,visible light is utilized to excite a substrate or a photosensitizer to catalyze the reaction; and in a reaction solvent, when aromatic hydrocarbon shown in the formula (1) and sodium bromide serve as raw materials, aryl bromide shown in the formula (2) is obtained through a reaction under the auxiliary action of an additive (protonic acid); or when aromatic hydrocarbon shown in the formula (1) and sodium iodide are used as raw materials, under the auxiliary action of an additive (protonic acid), aryl iodide shown in the formula (3) is obtained through reaction. The synthesis method has the advantages of cheap and accessible raw materials, simple reaction operation and mild reaction conditions. The method is compatible with the arylamine which is liable to be oxidized. The invention provides a new method for the synthesis of aryl halides, realizes the amplification of basic chemicals aryl halides including aryl bromide shown in the formula (2) and aryl iodide shown in the formula (3),and has wide application prospect and practical value.