474975-41-2

Basic information

• Product Name: 6-amino-2-methoxy-3-methyl-5-[3-(4-nitrophenyl)-3-oxopropyl]pyrimidin-4(3H)-one
• Synonyms: 6-amino-2-methoxy-3-methyl-5-[3-(4-nitrophenyl)-3-oxopropyl]pyrimidin-4(3H)-one
• CAS NO: 474975-41-2
• Molecular Weight: 332.316
• Mol File: 474975-41-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-amino-2-methoxy-3-methyl-5-[3-(4-nitrophenyl)-3-oxopropyl]pyrimidin-4(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-amino-2-methoxy-3-methyl-5-[3-(4-nitrophenyl)-3-oxopropyl]pyrimidin-4(3H)-one(474975-41-2)
• EPA Substance Registry System: 6-amino-2-methoxy-3-methyl-5-[3-(4-nitrophenyl)-3-oxopropyl]pyrimidin-4(3H)-one(474975-41-2)

Safety Data

• Hazardous Substances Data: 474975-41-2(Hazardous Substances Data)

Upstream product

• 94940-32-6 6-amino-2-methoxy-3-methylpyrimidin-4(3H)-one 
• 36994-29-3 3-dimethylamino-1-(4-nitrophenyl)propan-1-one hydrochloride 

Downstream Products

• 474975-42-3 7-hydroxy-2-methoxy-3-methyl-7-(4-nitrophenyl)-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-4(3H)-one 

Relevant articles and documents

New aspects on the selective synthesis of 7-arylpyrido[2,3-d]pyrimidines

Pyrido[2,3-d]pyrimidines have been synthesized via a selective cyclocondensation reaction between 6-aminopyrimidines 1 and the Mannich bases, propiophenone hydrochlorides 2. Intermediates for this reaction, such as the Michael addition adduct and the further hydrated pyrido[2,3-d]pyrimidine were isolated to prove the postulated mechanism. NMR analysis of bidimensional experiments allowed to determine unambiguously the process to obtain 7-arylpyrido[2,3-d]pyrimidines.