474975-42-3Relevant articles and documents
New aspects on the selective synthesis of 7-arylpyrido[2,3-d]pyrimidines
Quiroga, Jairo,Insuasty, Henry,Insuasty, Braulio,Abonía, Rodrigo,Cobo, Justo,Sánchez, Adolfo,Nogueras, Manuel
, p. 4873 - 4877 (2007/10/03)
Pyrido[2,3-d]pyrimidines have been synthesized via a selective cyclocondensation reaction between 6-aminopyrimidines 1 and the Mannich bases, propiophenone hydrochlorides 2. Intermediates for this reaction, such as the Michael addition adduct and the further hydrated pyrido[2,3-d]pyrimidine were isolated to prove the postulated mechanism. NMR analysis of bidimensional experiments allowed to determine unambiguously the process to obtain 7-arylpyrido[2,3-d]pyrimidines.