475-67-2 Usage
Description
Isocorydine is an aporphine alkaloid that has been found in A. squamosa that has vasodilatory and anticancer activities. It reduces the action potential duration and increases the effective refractory period in isolated canine Purkinje fibers when used at a concentration of 30 μM. Isocorydine induces relaxation of norepinephrine-precontracted isolated rabbit aortic strips with an EC50 value of 12.6 μM. It is cytotoxic to A549 lung cancer cells (IC50 = 197.7 μM), as well as Huh7, HepG2, SNU-449, and SNU-387 hepatic cancer cells (IC50s = 161.3, 148, 262.2, and 254.1 μg/ml, respectively). Isocorydine, in combination with doxorubicin, reduces tumor growth in a Huh7 mouse xenograft model.
Uses
Different sources of media describe the Uses of 475-67-2 differently. You can refer to the following data:
1. sedative, cholinergic
2. Isocorydine is an alkaloid inhibitor of eukaryotic kinases.
References
See Isocorydine
Check Digit Verification of cas no
The CAS Registry Mumber 475-67-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,7 and 5 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 475-67:
(5*4)+(4*7)+(3*5)+(2*6)+(1*7)=82
82 % 10 = 2
So 475-67-2 is a valid CAS Registry Number.
InChI:InChI=1/C20H23NO4/c1-21-8-7-12-10-15(24-3)20(25-4)18-16(12)13(21)9-11-5-6-14(23-2)19(22)17(11)18/h5-6,10,13,22H,7-9H2,1-4H3
475-67-2Relevant articles and documents
ALKALOIDS OF Glaucium fimbrilligerum
Karimova, S. U.,Israilov, I. A.,Yunusov, M. S.,Yunusov, S. Yu.
, p. 177 - 180 (1980)
From the epigeal part and roots of Glaucium fimbrilligerum 22 alkaloids have been isolated, of which three have proved to be new - d-isocorytuberine, dehydrocorydine, and coridine N-oxide.
Asymmetric total synthesis of (S)-isocorydine
Zhong, Mei,Jiang, Yunbin,Chen, Yali,Yan, Qian,Liu, Junxi,Di, Duolong
, p. 1145 - 1149 (2015/10/28)
The asymmetric total synthesis of (S)-isocorydine, a potential drug for the cure of hepatocellular carcinoma, is described. Asymmetric transfer hydrogenation of 3,4-dihydroisoquinoline using a chiral Ru(II) catalyst was applied to the synthesis of isocory
