475115-47-0Relevant academic research and scientific papers
Fused sulfur-containing pyridine systems: 1. Synthesis and structures of tetrahydropyridothienopyridinone and tetrahydropyridothiopyranopyridinone derivatives
Dotsenko,Krivokolysko,Chernega,Litvinov
, p. 969 - 977 (2003)
The reactions of N-methylmorpholinium 4-aryl(hetaryl)-5-cyano-2-oxo-1,2,3, 4-tetrahydropyridine-6-thiolates with malononitrile and acetone in ethanol afforded substituted tetrahydropyridothienopyridinones. In the absence of acetone, tetrahydropyridothiopyranopyridinones were isolated as the major reaction products. The latter were also synthesized independently by the reactions of the above-mentioned thiolates with 2-amino-1,1,3-tricyanopropene. The structure of 2,4-diamino-10-(2-chlorophenyl)-3-cyano-5-immo-8-oxo-7,8,9,10- tetrahydro-51T-pyrido[2',3':2,3]thiopyrano[4,5-b]pyridme was established by X-ray diffraction analysis.
A novel approach to the synthesis of partially hydrogenated dipyridothiophenes
Dotsenko, Victor V.,Krivokolysko, Sergey G.,Litvinov, Victor P.
, p. 30 - 31 (2004)
A new methodology for the synthesis of substituted tetrahydropyrido[3′,2′:4,5]thieno[3,2-b]pyridines and the mechanism of their formation are described.
2-Amino-9-aryl-3-cyano-4-methyl-7-oxo-6,7,8,9-tetrahydropyrido[2′,3′:4,5]thieno[2,3-b]pyridine derivatives as selective progesterone receptor agonists
Wang, Yonghui,Duraiswami, Chaya,Madauss, Kevin P.,Tran, Thuy B.,Williams, Shawn P.,Deng, Su-Jun,Graybill, Todd L.,Hammond, Marlys,Jones, David G.,Grygielko, Eugene T.,Bray, Jeffrey D.,Thompson, Scott K.
experimental part, p. 4916 - 4919 (2009/12/26)
High throughput screening of the corporate compound collection led to the identification of a novel series of 2-amino-9-aryl-3-cyano-4-methyl-7-oxo-6,7,8,9-tetrahydropyrido[2′,3′:4,5]thieno[2,3-b]pyridine derivatives as selective PR agonists. Initial SAR
