475272-63-0

Upstream product

• 353277-27-7 6-chloro-5-nitropyridine-2-carboxylic acid 
• 100-51-6 benzyl alcohol 
• 1416801-04-1 6-(benzyloxy)-5-nitropicolinaldehyde 
• 100-39-0 benzyl bromide 
• 353293-50-2 2-(Benzyloxy)-6-chloro-3-nitropyridine 
• 92138-35-7 6-chloro-3-nitro-1H-pyridin-2-one 
• 16013-85-7 2,6-dicholoro-3-nitropyridine 

Downstream Products

• 475272-86-7 Methyl 6-(benzyloxy)-5-{[(6-(benzyloxy)-5-{[(6-(benzyloxy)-5-nitro-2-pyridinyl)carbonyl]amino}-2-pyridinyl)carbonyl]amino}-2-pyridinecarboxylate 
• 475272-88-9 Methyl 6-(benzyloxy)-5-{[(6-(benzyloxy)-5-{[(6-isopropoxy-5-nitro-2-pyridinyl)carbonyl]amino}-2-pyridinyl)carbonyl]amino}-2-pyridinecarboxylate 
• 475272-87-8 Methyl 5-{[(6-(benzyloxy)-5-{[(6-isopropoxy-5-nitro-2-pyridinyl)carbonyl]amino}-2-pyridinyl)carbonyl]amino}-6-isopropoxy-2-pyridine carboxylate 
• 475272-82-3 Methyl 6-(benzyloxy)-5-{[(6-(benzyloxy)-5-nitro-2-pyridinyl)carbonyl]amino}-2-pyridinecarboxylate 
• 475272-73-2 Methyl 5-{[(5-amino-6-(benzyloxy)-2-pyridinyl)carbonyl]amino}-6-(benzyloxy)-2-pyridinecarboxylate 
• 475272-83-4 5-[(6-benzyloxy-5-nitro-pyridine-2-carbonyl)-amino]-6-isopropoxy-pyridine-2-carboxylic acid methyl ester 
• 475272-74-3 Methyl 5-{[(5-amino-6-(benzyloxy)-2-pyridinyl)carbonyl]amino}-6-isopropoxy-2-pyridinecarboxylate 
• 475272-70-9 Methyl 5-amino-6-(benzyloxy)-2-pyridinecarboxylate 
• 475272-67-4 Methyl 6-(benzyloxy)-5-nitro-2-pyridinecarboxylate 

Relevant academic research and scientific papers

BCL-2 INHIBITORS AND THEIR USE AS PHARMACEUTICALS

The disclosure is directed to, in part, to BCL-2 inhibitors, pharmaceutical compositions comprising the same, as well as methods of their use and preparation.

TRPM8 ANTAGONISTS AND THEIR USE IN TREATMENTS

Compounds of Formula (I) are useful as antagonists of TRPM8. Such compounds are useful in treating a number of TRPM8 mediated disorders and conditions and may be used to prepare medicaments and pharmaceutical compositions useful for treating such disorders and conditions. Examples of such disorders include, but are not limited to, migraines and neuropathic pain. Compounds of Formula (I) have a structure where the definitions of the variables are provided herein.

Design and application of an α-helix-mimetic scaffold based on an oligoamide-foldamer strategy: Antagonism of the Bak BH3/Bcl-xL complex

The prevention of cell death by the antiapoptotic protein Bcl-xL has been linked to a number of cancers. Bcl-xl binds to the BH3 domain of the proapoptotic protein Bak, thus preventing programmed cell death. A competitive assay and docking studies have shown that the polyamide scaffold 1, which was synthesized based on a rational structure-based design, interferes with the Bak BH3/Bcl-xl complexation.

Proteomimetic compounds and methods

The present invention relates to compounds and pharmaceutical compositions which are proteomimetic and to methods for inhibiting the interaction of an alpha-helical protein with another protein or binding site. Methods for treating diseases or conditions which are modulated through interactions between alpha helical proteins and their binding sites are other aspects of the invention.