475279-74-4

Usage

Class

Piperazines are a class of heterocyclic compounds containing a six-membered ring with four carbon atoms and two nitrogen atoms.

Functional group

The presence of a 5-fluoro-2-nitrophenyl group suggests potential pharmacological or biological activities.

Ester derivative

The 1,1-dimethylethyl ester group indicates that 1-Piperazinecarboxylic acid, 4-(5-fluoro-2-nitrophenyl)-, 1,1-dimethylethyl ester is an ester derivative of 1-piperazinecarboxylic acid.

Common uses of esters

Esters are commonly used as solvents, plasticizers, and fragrance ingredients.

Potential applications

The chemical structure of 1-Piperazinecarboxylic acid, 4-(5-fluoro-2-nitrophenyl)-, 1,1-dimethylethyl ester suggests that it may have applications in pharmaceutical, agricultural, or industrial processes.

Further studies needed

Further studies may be necessary to determine the specific properties and potential uses of 1-Piperazinecarboxylic acid, 4-(5-fluoro-2-nitrophenyl)-, 1,1-dimethylethyl ester.

Upstream product

• 446-35-5 2,4-Difluoronitrobenzene 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 

Relevant academic research and scientific papers

N2,N4-BIS(4-(PIPERAZINE-1-YL)PHENYL)PIRIMIDINE-2,4-DIAMINE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING CANCER

The present invention relates to a N2,N4-bis(4-(piperazine-1-yl)phenyl)pirimidine-2,4-diamine derivative or a pharmaceutically acceptable salt thereof, and to a composition containing same as an active ingredient for preventing or treating cancer. Since the compound according to the present invention has good effects in inhibiting the activities of anaplastic lymphoma kinase (ALK) and activated Cdc42-associated kinase (ACK1), the compound can have improved therapeutic effects against cancer cells having ALK fusion proteins such as EML4-ALK and NPM-ALK and is expected to be effective in preventing the recurrence of cancer. Therefore, the compound can be effectively used as a composition for preventing or treating cancer.

Nonpolar solvent a key for highly regioselective SNAr reaction in the case of 2,4-difluoronitrobenzene

A practical and highly regioselective aromatic nucleophilic substitution reaction for the substrate 2,4-difluoronitrobenzene is demonstrated with various O/S/N-nucleophiles. Solvent screens substantiate the role of a nonpolar solvent in ortho-selective nucleophilic substitution through a six-membered polar transition state.

Dramatic effect of solvent hydrogen bond basicity on the regiochemistry of SNAr reactions of electron-deficient polyfluoroarenes

[Chemical Equation Presented] It was found that solvent hydrogen bond basicity (SHBB) significantly affects the regiochemistry of the SNAr reaction between secondary amines and activated polyfluoroarenes. A plausible mechanism involving a six-m

SUBSTITUTED ARYLAMINE COMPOUNDS AND THEIR USE AS 5-HT6 MODULATORS

The invention relates to 5-HT6 receptor antagonists. Novel arylamine compounds having the formula: (see formula I) and pharmaceutically acceptable salts and/or esters thereof, wherein - n is 0, 1, 2, 3, or 4; - A, when present is a lower alkyl

[Bmim]PF6 and BF4 ionic liquids as novel and recyclable reaction media for aromatic amination

Activated aryl halides undergo smooth nucleophilic substitution reactions with secondary amines in 1-butyl-3-methylimidazolium hexafluorophosphate ([bmim]PF6) or 1-butyl-3-methylimidazolium tetrafluoroborate ([bmim]BF4) ionic liquids (ILs) at room temperature to afford the corresponding arylamines in excellent yields under mild and neutral conditions.