475503-58-3

Upstream product

• 475479-07-3 (S)-1-[(S)-3-tert-Butoxycarbonylamino-2-(2-trimethylsilanyl-ethoxycarbonylamino)-propionyl]-pyrrolidine-2-carboxylic acid 
• 24424-99-5 di-tert-butyl dicarbonate 
• 51219-19-3 N^α-tert-butoxycarbonyl-N^δ,N^ω-di-benzyloxycarbonyl-L-arginine 
• 475503-62-9 (S)-1-[(S)-3-tert-Butoxycarbonylamino-2-(2-trimethylsilanyl-ethoxycarbonylamino)-propionyl]-pyrrolidine-2-carboxylic acid benzyl ester 
• 475479-08-4 3-tert-butoxycarbonylamino-2-(2-trimethylsilanyl-ethoxycarbonylamino)-propionic acid 
• 446064-62-6 N^α-Boc-N^δ,N^ε-Z₂-Arg-C(PPH3)CN 
• 16640-68-9 cyanomethylene triphenylphosphorane 

Downstream Products

• 475503-59-4 C₇₁H₁₀₅N₉O₁₆Si₂ 

Relevant academic research and scientific papers

Application of cyano ylide methodology to the synthesis of cyclotheonamides E2 and E3

A total synthesis of cyclotheonamides E2 and E3 is reported. A key step in the synthesis involves the formation of the α-keto amide linkage by application of the cyano ylide activation of a carboxyl group as developed in our earlier syntheses of cyclic peptide protease inhibitors.