475504-31-5

Basic information

• Product Name: 1-Benzyl 2-methyl (2R,4S)-4-hydroxy-1,2-piperidinedicarboxylate
• Synonyms: 1,2-Piperidinedicarboxylic acid, 4-hydroxy-,2-methyl 1-(phenylmethyl) ester, (2R,4S)-;1,2-Piperidinedicarboxylic acid, 4-hydroxy-, 2-methyl 1-(phenylmethyl) ester, (2R,4S)-
• CAS NO: 475504-31-5
• Molecular Formula: C15H19NO5
• Molecular Weight: 293.32
• Mol File: 475504-31-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-Benzyl 2-methyl (2R,4S)-4-hydroxy-1,2-piperidinedicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Benzyl 2-methyl (2R,4S)-4-hydroxy-1,2-piperidinedicarboxylate(475504-31-5)
• EPA Substance Registry System: 1-Benzyl 2-methyl (2R,4S)-4-hydroxy-1,2-piperidinedicarboxylate(475504-31-5)

Safety Data

• Hazardous Substances Data: 475504-31-5(Hazardous Substances Data)

Usage

Type

Chemical compound
With pharmacological properties

Use

Medication for treating Parkinson's disease and Parkinsonian tremors
By blocking the action of certain neurotransmitters in the brain

Mechanism of action

Antagonist at muscarinic acetylcholine receptors
Involved in movement and muscle control

Chemical structure

Derivative of the tropane alkaloid
Structurally related to atropine
Includes a benzyl group, a methyl group, and a piperidine ring
Contains a hydroxy and carboxylate group

Duration of action

Relatively long

Forms available

Oral and injectable
For clinical use

Upstream product

• 127474-54-8 (R)-2-(benzyloxycarbonylamino)pent-4-enoic acid 
• 127515-28-0 (R)-methyl 2-[N-(benzyloxycarbonyl)amino]-4-pentenoate 
• 50299-14-4 N-Acetyl-α-allylglycine 
• 475504-29-1 (2R)-4-formylpipecolic acid methyl ester 
• 501-53-1 benzyl chloroformate 
• 211058-81-0 methyl (2R,4S)-4-hydroxy-2-piperidinecarboxylate 

Downstream Products

• 321744-26-7 N-Boc-4-hydroxy-2-piperidine carboxylic acid methyl ester 
• 475504-32-6 (2R,4R)-4-hydroxypipecolic acid methyl ester 
• 211055-76-4 (2R,4S)-4-(2,4-Dichloro-phenoxy)-piperidine-2-carboxylic acid methyl ester 

Relevant articles and documents

Use of hydrolases for the synthesis of cyclic amino acids

The synthesis of several cyclic amino acids that have all the necessary structural features to make them ideal scaffolds for use in medicinal chemistry is described. A key step in each synthesis is the use of hydrolase enzymes to define a chiral centre. I

Novel constrained CCK-B dipeptoid antagonists derived from pipecolic acid

A new series of 4-substituted pipecolic acid derivatives was prepared and incorporated into dipeptoids. The resulting products behave as moderately potent CCK-B antagonists but their constrained structure and its comparison with structurally related compounds yield valuable information about the conformational requirements for optimal recognition of the CCK-B receptor by antagonists.