475577-03-8Relevant academic research and scientific papers
Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 2. Structure-activity relationships of the 7- and 5-, 6-, 8-positions
Kemnitzer, William,Kasibhatla, Shailaja,Jiang, Songchun,Zhang, Hong,Zhao, Jianghong,Jia, Shaojuan,Xu, Lifen,Crogan-Grundy, Candace,Denis, Real,Barriault, Nancy,Vaillancourt, Louis,Charron, Sylvie,Dodd, Jennifer,Attardo, Giorgio,Labrecque, Denis,Lamothe, Serge,Gourdeau, Henriette,Tseng, Ben,Drewe, John,Cai, Sui Xiong
, p. 4745 - 4751 (2007/10/03)
As a continuation of our efforts to discover and develop the apoptosis inducing 4-aryl-4H-chromenes as novel anticancer agents, we explored the SAR of 4-aryl-4H-chromenes with modifications at the 7- and 5-, 6-, 8-positions. It was found that a small hydr
