475577-01-6Relevant academic research and scientific papers
Discovery of 4-aryl-2-oxo-2H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay
Kemnitzer, William,Jiang, Songchun,Zhang, Hong,Kasibhatla, Shailaja,Crogan-Grundy, Candace,Blais, Charles,Attardo, Giorgio,Denis, Real,Lamothe, Serge,Gourdeau, Henriette,Tseng, Ben,Drewe, John,Cai, Sui Xiong
scheme or table, p. 5571 - 5575 (2009/05/30)
As a continuation of our efforts to discover and develop the apoptosis inducing 4-aryl-4H-chromenes as potential anticancer agents, we explored the removal of the chiral center at the 4-position and prepared a series of 4-aryl-2-oxo-2H-chromenes. It was f
Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 2. Structure-activity relationships of the 7- and 5-, 6-, 8-positions
Kemnitzer, William,Kasibhatla, Shailaja,Jiang, Songchun,Zhang, Hong,Zhao, Jianghong,Jia, Shaojuan,Xu, Lifen,Crogan-Grundy, Candace,Denis, Real,Barriault, Nancy,Vaillancourt, Louis,Charron, Sylvie,Dodd, Jennifer,Attardo, Giorgio,Labrecque, Denis,Lamothe, Serge,Gourdeau, Henriette,Tseng, Ben,Drewe, John,Cai, Sui Xiong
, p. 4745 - 4751 (2007/10/03)
As a continuation of our efforts to discover and develop the apoptosis inducing 4-aryl-4H-chromenes as novel anticancer agents, we explored the SAR of 4-aryl-4H-chromenes with modifications at the 7- and 5-, 6-, 8-positions. It was found that a small hydr
Substituted 4H-chromenes and analogs as activators of caspases and inducers of apoptosis and the use thereof
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, (2008/06/13)
The present invention is directed to substituted 4H-chromenes and analogs thereof, represented by the general Formula I: 1wherein R1-R5, A, Y and Z are defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
Substituted coumarins and quinolines and analogs as activators of caspases and inducers of apoptosis and the use thereof
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, (2008/06/13)
The present invention is directed to substituted coumarins and quinolines and analogs thereof, represented by the general Formula I: wherein A, B, X, Y, and Z are defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
