475577-32-3Relevant academic research and scientific papers
Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high throughput screening assay. 4. Structure-activity relationships of N-alkyl substituted pyrrole fused at the 7,8-positions
Kemnitzer, William,Drewe, John,Jiang, Songchun,Zhang, Hong,Crogan-Grundy, Candace,Labreque, Denis,Bubenick, Monica,Attardo, Giorgio,Denis, Real,Lamothe, Serge,Gourdeau, Henriette,Tseng, Ben,Kasibhatla, Shailaja,Sui, Xiong Cai
, p. 417 - 423 (2008/09/20)
In our continuing effort to discover and develop apoptosis inducing 4-aryl-4H-chromenes as novel anticancer agents, we explored the structure-activity relationship (SAR) of alkyl substituted pyrrole fused at the 7,8-positions. A methyl group substituted a
Substituted 4H-chromenes and analogs as activators of caspases and inducers of apoptosis and the use thereof
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, (2008/06/13)
The present invention is directed to substituted 4H-chromenes and analogs thereof, represented by the general Formula I: 1wherein R1-R5, A, Y and Z are defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
