475577-33-4

Usage

Chemical class

Indole derivatives

Physical appearance

White to light yellow crystalline substance

Uses

Synthesis of pharmaceuticals and fine chemicals

Biological activities

Potential medicinal properties, including anti-inflammatory and antimicrobial effects

Handling precautions

May pose health risks if not properly handled or disposed of.

Upstream product

• 2380-84-9 7-Indolol 
• 553-90-2 Dimethyl oxalate 
• 20289-27-4 7-benzyloxyindole 

Downstream Products

• 135855-62-8 1-methyl-1H-indol-6-ylamine 
• 475577-32-3 2-Amino-4-(3-bromo-4,5-dimethoxyphenyl)-3-cyano-9-methyl-4H-pyrrolo[3,2-h]chromene 

Relevant academic research and scientific papers

One-Pot Generation of Benzynes from Phenols: Formation of Primary Anilines by the Deoxyamination of Phenols

Benzynes were selectively generated in situ from phenols and trapped regioselectively with potassium hexamethyldisilazide to form primary anilines following acidic workup. The direct conversion of a phenolic hydroxyl group into a free amino group is a useful method for the preparation of primary aryl amines that are hard to synthesize by using coupling reactions involving phenol derivatives with ammonia. Whereas reactions of ortho- and meta-substituted phenols produced meta-substituted anilines exclusively, those of para-substituted phenols provided ortho-silylanilines.

Substituted 4H-chromenes and analogs as activators of caspases and inducers of apoptosis and the use thereof

The present invention is directed to substituted 4H-chromenes and analogs thereof, represented by the general Formula I: 1wherein R1-R5, A, Y and Z are defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.