475650-15-8Relevant academic research and scientific papers
Identification of potent and selective oxytocin antagonists. Part 1: Indole and benzofuran derivatives
Wyatt, Paul G.,Allen, Michael J.,Chilcott, Josie,Foster, Alison,Livermore, David G.,Mordaunt, Jackie E.,Scicinski, Jan,Woollard, Patrick M.
, p. 1399 - 1404 (2007/10/03)
Studies to discover novel, potent and selective oxytocin antagonists are reported. Combinatorial libraries designed to find novel replacements of fragments of oxytocin antagonist L-371,257, identified pyrimidine, thiazole, indole and benzofuran as potential alternatives to the benzoic acid moiety of L-371,257. Additional investigations identified indole and benzofuran derivatives with potent oxytocin antagonist activity.
