58123-77-6Relevant academic research and scientific papers
Method for preparing benzo oxygen-containing aliphatic heterocyclic derivative
-
Paragraph 0046-0048, (2021/02/10)
The invention relates to a method for preparing a benzo oxygen-containing aliphatic heterocyclic derivative, which specifically comprises the following steps: (1) carrying out nitration reaction on acompound shown as a formula I-1 to obtain a compound shown as a formula I-2; (2) carrying out reduction reaction on the compound shown in the formula I-2 to obtain a compound shown in a formula I-3; (3) performing halogenation reaction on the compound shown in the formula I-3 to obtain a compound shown in a formula I-4; (4) carrying out diazotization reaction on the compound shown as the formula I-4, and further reacting the obtained product with a halogenated metal salt to generate a compound shown as a formula I;.
Synthesis of multifunctional metal-organic frameworks and tuning the functionalities with pendant ligands
Prasad, Thazhe Kootteri,Suh, Myunghyun Paik
supporting information, p. 15034 - 15040 (2020/11/11)
A series of multifunctional metal-organic frameworks (MOFs), SNU-170-SNU-176, has been synthesized using ligands, in which various functional pendants such as -NH2, -SMe, -OMe, -OEt, -OPr, and -OBu are attached to the phenyl ring of 4-(2-carboxyvinyl)benz
IRAK4 INHIBITORS AND USES THEREOF
-
Paragraph 0125, (2019/05/22)
Compounds of Formula I as IRAK4 inhibitors are disclosed. The pharmaceutical compositions comprising compounds of formula I, methods of synthesis of these compounds, methods of treatment for diseases associated with IRAK-4 such as inflammatory diseases an
Preparation method of intermediate of medicine for treating chronic dry eye
-
Paragraph 0011; 0013; 0014; 0015, (2018/09/26)
The invention relates to a preparation method of an intermediate of a medicine for treating chronic dry eye. The method comprises the following steps: (a) adding methyl alcohol, m-hydroxybenzoic acid,NaOH and NaI to a reaction vessel; and dropwise adding
Photopatterning of fluorescent host-guest carriers through pore activation of metal-organic framework single crystals
Stassen,Boldog,Steuwe,De Vos,Roeffaers,Furukawa,Ameloot
supporting information, p. 7222 - 7225 (2017/07/11)
Encoded fluorescent particles are fabricated through the selective uptake of dyes in photopatterned metal-organic framework single crystals. The concept is based on spatially controlled photochemical cleavage of pore-blocking pendant groups. Because of the crystalline and porous nature of the host, this approach enables guest uptake that is tunable and can be triggered though controlled irradiation.
ARYLOXYACETYLINDOLES AND ANALOGS AS ANTIBIOTIC TOLERANCE INHIBITORS
-
Paragraph 0646, (2016/08/10)
The disclosure provides compounds and pharmaceutical compositions of aryloxyacetylindoles compounds and analogs useful for treating chronic and acute bacterial infections. Certain of the compounds are compounds of general Formula (I) (I) or a pharmaceutically acceptable salt or prodrug thereof. Certain compounds of this disclosure are MvfR inhibitors. MvfR inhibitors reduce the formation of antibiotic tolerant bacterial strains and are useful for treating Gram-negative bacterial infections and reducing the virulence of Pseudomonas aeruginosa. Methods of treating bacterial infections in a subject, including Pseudomonas aeruginosa infections, are also provided by the disclosure.
Three sra topological lanthanide-organic frameworks built from 2,2′-dimethoxy-4,4′-biphenyldicarboxylic acid
Wang, Xin,Zhao, Jie,Zhao, Yan,Xu, Heng,Shen, Xuan,Zhu, Dun-Ru,Jing, Su
supporting information, p. 9281 - 9288 (2015/05/20)
Three 3D lanthanide-organic frameworks (LOFs), [LnL(HCO2)(DMF)]n (Ln = Eu (1), Gd (2), Dy (3); H2L = 2,2′-dimethoxy-4,4′-biphenyldicarboxylic acid), have been prepared by the solvothermal reaction of Ln(NO3)sub
Bicyclic-Fused Heteroaryl or Aryl Compounds
-
Paragraph 0398, (2015/10/28)
Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula Ia, as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
Synthesis and antibacterial evaluation of new, unsymmetrical triaryl bisamidine compounds
Nguyen, Son T.,Williams, John D.,Butler, Michelle M.,Ding, Xiaoyuan,Mills, Debra M.,Tashjian, Tommy F.,Panchal, Rekha G.,Weir, Susan K.,Moon, Chaeho,Kim, Hwa-Ok,Marsden, Jeremiah A.,Peet, Norton P.,Bowlin, Terry L.
supporting information, p. 3366 - 3372 (2014/07/22)
Herein we describe the synthesis and antibacterial evaluation of a new, unsymmetrical triaryl bisamidine compound series, [Am]-[indole]-[linker]-[HetAr/ Ar]-[Am], in which [Am] is an amidine or amino group, [linker] is a benzene, thiophene or pyridine ring, and [HetAr/Ar] is a benzimidazole, imidazopyridine, benzofuran, benzothiophene, pyrimidine or benzene ring. When the [HetAr/Ar] unit is a 5,6-bicyclic heterocycle, it is oriented such that the 5-membered ring portion is connected to the [linker] unit and the 6-membered ring portion is connected to the [Am] unit. Among the 34 compounds in this series, compounds with benzofuran as the [HetAr/Ar] unit showed the highest potencies. Introduction of a fluorine atom or a methyl group to the triaryl core led to the more potent analogs. Bisamidines are more active toward bacteria while the monoamidines are more active toward mammalian cells (as indicated by low CC 50 values). Importantly, we identified compound P12a (MBX 1887) with a relatively narrow spectrum against bacteria and a very high CC50 value. Compound P12a has been scaled up and is currently undergoing further evaluations for therapeutic applications.
Control of framework interpenetration for in situ modified hydroxyl functionalised IRMOFs
Rankine, Damien,Avellaneda, Antonio,Doonan, Christian J.,Sumby, Christopher J.,Hill, Matthew R.
supporting information, p. 10328 - 10330,3 (2020/09/09)
By intimate control of reaction conditions, phase-pure crystalline porous metal-organic framework materials [Zn4O(L)3] with interpenetrated and non-interpenetrated structures can be synthesised. Under certain conditions, these reacti
