475650-94-3

Upstream product

• 241129-82-8 Acetic acid (3R,4R,5S,6R)-6-acetoxymethyl-5-allyloxy-3-azido-4-benzyloxy-tetrahydro-pyran-2-yl ester 
• 105265-70-1 (1R,2S,3R,4R,5R)-2-Allyloxy-4-azido-3-benzyloxy-6,8-dioxa-bicyclo[3.2.1]octane 
• 13265-84-4 D-glucal 
• 100-39-0 benzyl bromide 

Downstream Products

• 120312-13-2 4-O-allyl-2-azido-3,6-di-O-benzyl-2-deoxy-α-D-glucopyranosyl fluoride 
• 475650-99-8 6-O-[2-azido-3,6-di-O-benzyl-2-deoxy-4-O-(2-propenyl)-α-D-glucopyranosyl]-2-O-hexadecanoyl-1-O-(p-methoxybenzyl)-3,4,5-tri-O-benzyl-myo-inositol 
• 543698-59-5 6-O-(2-azido-3,6-di-O-benzyl-2-deoxy-α-D-glucopyranosyl)-2-O-hexadecanoyl-1-O-(p-methoxybenzyl)-3,4,5-tri-O-benzyl-myo-inositol 
• 475651-00-4 6-O-[2-azido-3,6-di-O-benzyl-2-deoxy-4-O-(2-propenyl)-α-D-glucopyranosyl]-2-O-hexadecanoyl-3,4,5-tri-O-benzyl-myo-inositol 
• 475650-87-4 (2R,3S,4R,5R)-3-Allyloxy-5-azido-4-benzyloxy-2-benzyloxymethyl-6-fluoro-tetrahydro-pyran 
• 475650-96-5 4-O-allyl-2-azido-3-O-benzyl-2-deoxy-D-glucopyranosyl fluoride 

Relevant academic research and scientific papers

First total synthesis of a GPI-anchored peptide

A GPI-anchored dipeptide of sperm CD52 antigen was prepared through a convergent synthesis. First, the dipeptide with its C-terminus free and the GPI with its nonreducing end phosphoeth-anolamine bearing a free amino group were synthesized separately. Then, the two building blocks were coupled with use of EDC/HOBt as the condensation reagent. Finally, the GPI-anchored peptide was deprotected to give the target molecule 1.

Convergent synthesis of an inner core GPI of sperm CD52

An inner core of the GPI anchor of sperm CD52 antigens was synthesized by a highly convergent process using specially modified inositol, glucosamine and phospholipid as key building blocks. This paper also presents a new and efficient procedure to prepare