475995-39-2Relevant academic research and scientific papers
Aminomethylpyrimidines as novel DPP-IV inhibitors: A 105-fold activity increase by optimization of aromatic substituents
Peters, Jens-Uwe,Weber, Silja,Kritter, Stephane,Weiss, Peter,Wallier, Angelina,Boehringer, Markus,Hennig, Michael,Kuhn, Bernd,Loeffler, Bernd-Michael
, p. 1491 - 1493 (2007/10/03)
The influence of aromatic substitution on a newly discovered class of inhibitors of dipeptidyl peptidase IV was investigated. A 105-fold increase in potency was achieved by the optimization of aromatic substituents in a parallel chemistry progr
Synthesis of new 4-amino-2,6-diarylpyrimidine-5-carbonitriles
De Melo, Sebastiao Jose,Dos Santos, Leila Cabral,Da S. Falcao, Emerson Peter,Srivastava, Rajendra M.,Luu-Duc
, p. 216 - 217 (2007/10/03)
A facile synthesis of the title compounds 5a-e, from appropriate amidines and benzylidenemalononitriles, is described.
