475998-01-7Relevant academic research and scientific papers
Crystal structure, antitumour and antimetastatic activities of disubstituted fused 1,2,4-triazinones
Sztanke, Krzysztof,Pasternak, Kazimierz,Sztanke, Malgorzata,Kandefer-Szerszen, Martyna,Koziol, Anna E.,Dybala, Izabela
scheme or table, p. 5095 - 5100 (2010/03/31)
Molecular structure of 3,8-disubstituted 7,8-dihydroimidazo[2,1-c][1,2,4]triazin-4(6H)-ones (8-14) was confirmed by X-ray crystallography of 14. All the compounds were evaluated for their antitumour and antimetastatic activities in vitro. Furthermore, their cytotoxicities towards human normal cell line-HSF cells were established, allowing us to point out some structure-activity relationships. Among them, imidazotriazinone 12, revealing remarkable dose-dependent viability decreases in human myeloma RPMI 8226 cells, was found to be completely non-toxic towards normal HSF cells. In addition, heterobicycles 8-12 were proved to exhibit significant antimetastatic potentials in the motility assay.
Synthesis of imidazoline and imidazo[2,1-c][1,2,4]triazole aryl derivatives containing the methylthio group as possible antibacterial agents
Sztanke, Krzysztof,Pasternak, Kazimierz,Sidor-Wójtowicz, Anna,Truchlińska, Janina,Jó?wiak, Krzysztof
, p. 3635 - 3642 (2007/10/03)
1-Arylimidazolidine-2-thiones (1a-g) were synthesized by the condensation reaction of N-arylethylenediamines with carbon disulfide in xylene medium. Their further alkylation with methyl iodide led to the formation of some biologically active 1-aryl-2-meth
