476015-19-7Relevant articles and documents
Synthesis of C8-C8/C2-C8-linked triazolo pyrrolobenzodiazepine dimers by employing 'click' chemistry and their DNA-binding affinity
Kamal, Ahmed,Prabhakar,Shankaraiah,Reddy, Ch. Ratna,Reddy, P. Venkat
, p. 3620 - 3624 (2008/09/21)
A series of 1,2,3-triazole-containing pyrrolo[2,1-c][1,4]benzodiazepine dimers have been prepared efficiently by employing a 'click' chemistry protocol. This method involves 1,3-dipolar cycloaddition of terminal alkynes with organic azides using a Cu(I)-c
Design, synthesis, and evaluation of new noncross-linking pyrrolobenzodiazepine dimers with efficient DNA binding ability and potent antitumor activity
Kamal, Ahmed,Ramesh,Laxman,Ramulu,Srinivas,Neelima,Kondapi, Anand K.,Sreenu,Nagarajaram
, p. 4679 - 4688 (2007/10/03)
New sequence selective mixed imine-amide pyrrolobenzodiazepine (PBD) dimers have been developed that are comprised of DC-81 and dilactam of DC-81 subunits tethered to their C8 positions through alkanedioxy linkers (comprised of three to five and eight car