476015-19-7

Upstream product

• 105089-88-1 (2S)-2-[di(ethylsulfanyl)methyl]tetrahydro-1H-pyrrole 
• 4549-32-0 1,8-dibromooctane 
• 140647-02-5 (2S)-N-(4-hydroxy-5-methoxy-2-nitrobenzoyl)pyrrolidine-2-carboxaldehyde diethyl thioacetal 
• 476015-17-5 methyl 4-(8-bromooctyloxy)-5-methoxy-2-nitrobenzoate 
• 476015-18-6 4-(8-bromooctyloxy)-5-methoxy-2-nitrobenzoic acid 
• 476015-16-4 methyl 4-(3-bromooctyloxy)-3-methoxybenzoate 
• 3943-74-6 4-hydroxy-3-methoxybenzoic acid methyl ester 

Downstream Products

• 476015-21-1 (2S)-N-{4-[3-(7-methoxy-(11aS)-1,2,3,10,11,11a-hexahydro-5H-pyrrolo[2,1-c]-[1,4]benzodiazepine-5,11-dione-8-yloxy)octyloxy]-5-methoxy-2-nitrobenzoyl}pyrrolidine-2-carboxaldehyde diethyl thioacetal 
• 1037070-19-1 C₂₅H₃₉N₅O₅S₂ 
• 476015-22-2 (2S)-N-{4-[3-(7-methoxy-(11aS)-1,2,3,10,11,11a-hexahydro-5H-pyrrolo[2,1-c]-[1,4]benzodiazepine-5,11-dione-8-yloxy)octyloxy]-5-methoxy-2-aminobenzoyl}pyrrolidine-2-carboxaldehyde diethyl thioacetal 
• 476015-20-0 (2S)-N-{4-[methyl-(2S)-N-(5-methoxy-2-nitrobenzoyl)pyrrolidine-2-carboxylate-4-yloxy]octyloxy-5-methoxy-2-nitrobenzoyl}pyrrolidine-2-carboxaldehyde diethyl thioacetal 

Relevant academic research and scientific papers

Synthesis of C8-C8/C2-C8-linked triazolo pyrrolobenzodiazepine dimers by employing 'click' chemistry and their DNA-binding affinity

A series of 1,2,3-triazole-containing pyrrolo[2,1-c][1,4]benzodiazepine dimers have been prepared efficiently by employing a 'click' chemistry protocol. This method involves 1,3-dipolar cycloaddition of terminal alkynes with organic azides using a Cu(I)-c

Design, synthesis, and evaluation of new noncross-linking pyrrolobenzodiazepine dimers with efficient DNA binding ability and potent antitumor activity

New sequence selective mixed imine-amide pyrrolobenzodiazepine (PBD) dimers have been developed that are comprised of DC-81 and dilactam of DC-81 subunits tethered to their C8 positions through alkanedioxy linkers (comprised of three to five and eight car