476153-94-3

Upstream product

• 139326-94-6 1,2:3,4-di-O-isopropylidene-5,6-di-O-mesyl-D-mannitol 
• 476153-91-0 (1R,2S,3R)-1-phenyl-pent-4-ene-1,2,3-triol 
• 3969-59-3 mannitol triacetonide 
• 69-65-8 mannitol 
• 476153-90-9 (S)-((4R,5R)-2,2-dimethyl-5-vinyl-1,3-dioxolan-4-yl)(phenyl)methanol 
• 4105-60-6 2,3-O-isopropylidene-D-threo-4-pentenose 
• 168109-89-5 (1R)-1-((4R,5R)-2,2-dimethyl-5-vinyl[1,3]dioxolan-4-yl)ethane-1,2-diol 
• 4239-90-1 (4S,4'R,5R)-2,2,2',2'-tetramethyl-5-vinyl-4,4'-bi(1,3-dioxolane) 
• 201230-82-2 carbon monoxide 
• 476153-92-1 (1S,2S,3R)-1-phenyl-pent-4-ene-1,2,3-triol 

Relevant academic research and scientific papers

Homogeneous cyclocarbonylation of alkenols with iron pentacarbonyl

We report substantially improved reaction conditions for palladium(II)-catalyzed tandem cyclization-intramolecular oxycarbonylation of (amino)polyols with a terminal double bond, based on utilization of iron pentacarbonyl [Fe(CO)5] as an affordable and safe liquid supply of the carbonyl unit fully replacing gaseous carbon monoxide. Direct comparison with the classical version on a series of previously published substrates illustrates invariably shorter reaction times but comparable yields and selectivity. Georg Thieme Verlag Stuttgart · New York.

Synthesis of (+)-goniothalesdiol and (+)-7-epi-goniothalesdiol

A total synthesis of (+)-goniothalesdiol, a 3,4-dihydroxy-2,5-disubstituted tetrahydrofuran isolated from Goniothalamus borneensis (Annonaceae), and its 7-epimer is reported using oxycarbonylation methodology for construction of polyhydroxylated substitut

Preparation and crystal structure of (1S, 5S, 7S, 8R)-8-hydroxy-7-phenyl-2, 6-dioxabicyclo[3.3.0]octan-3-one

The absolute configuration at two newly formed stereogenic centres (5S, 7S) during the key steps of the total synthesis of naturally occuring goniothalesdiol was established by single-crystal X-ray diffraction analysis relative to stereocentres (1S, 8R) o

The first total synthesis of goniothalesdiol

The first total synthesis of goniothalesdiol, a dihydroxylated tetrahydrofuran isolated from Goniothalamus borneensis (Annonaceae), and its 7-epimer is described starting with D-mannitol. The key step of these syntheses is palladium(II)-catalyzed oxycarbo