476156-45-3

Upstream product

• 1187972-13-9 tert-butyl [(2R,3R,4R,5R)-3,4-bis(benzyloxy)-2-(hydroxymethyl)-5-(3-oxobutyl)]pyrrolidine-1-carboxylate 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 476156-42-0 (2R,3R,4R,5R)-3,4-dibenzyloxy-N-tert-butyloxycarbonyl-2'-O-tert-butyldiphenylsilyl-2,5-bis(hydroxymethyl)pyrrolidine 
• 476156-43-1 [(2'S,3'R,4'R,5'R)-3',4'-dibenzyloxy-N-tert-butyloxycarbonyl-5'-tert-butyldiphenylsilyloxymethylpyrrolidin-2'-yl]carbaldehyde 
• 476156-44-2 (E)-4-[(2'R,3'R,4'R,5'R)-3',4'-dibenzyloxy-N-tert-butyloxycarbonyl-5'-tert-butyldiphenylsilyloxymethylpyrrolidin-2'-yl]but-3-en-2-one 

Relevant academic research and scientific papers

Stereoselective syntheses of the glycosidase inhibitors hyacinthacine A2, hyacinthacine A3 and 5-epi-hyacinthacine A3

Stereoselective syntheses of the naturally occurring glycosidase inhibitors hyacinthacines A2 and A3 are reported. In the case of hyacinthacine A2, the pyrrolizidine system was created from an acyclic precursor via a doubl

Polyhydroxylated pyrrolizidines. Part 2: The first total synthesis of (+)-hyacinthacine A3

The first total synthesis for the (+)-hyacinthacine A3 1 in a highly stereocontrolled manner, is reported herein. An appropriately protected polyhydroxylated pyrrolidine, such as (2R,3R,4R,5R)-3,4-dibenzyloxy-N-tert-butyloxycarbonyl-2′-O-tert-