476169-20-7

Basic information

• Product Name: (4R)-4-(2-allylphenoxymethyl)-1,3,2-dioxathiolane 2-oxide
• Synonyms: (4R)-4-(2-allylphenoxymethyl)-1,3,2-dioxathiolane 2-oxide
• CAS NO: 476169-20-7
• Molecular Weight: 254.307
• Mol File: 476169-20-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (4R)-4-(2-allylphenoxymethyl)-1,3,2-dioxathiolane 2-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: (4R)-4-(2-allylphenoxymethyl)-1,3,2-dioxathiolane 2-oxide(476169-20-7)
• EPA Substance Registry System: (4R)-4-(2-allylphenoxymethyl)-1,3,2-dioxathiolane 2-oxide(476169-20-7)

Safety Data

• Hazardous Substances Data: 476169-20-7(Hazardous Substances Data)

Upstream product

• 476169-18-3 (S)-3-(2-allylphenoxy)propane-1,2-diol 
• 1745-81-9 o-Allylphenol 

Downstream Products

• 23846-71-1 (S)-alprenolol 

Relevant articles and documents

Cyclic sulfites, key intermediates in synthesis of 1-alkylamino-3-aryloxy-2-propanols from glycidol

A number of 3-aryloxypropanedioles were obtained by treating glycidol with phenols. The latter with thionyl chloride afforded 4-aryloxymethyl-1,3,2-dioxathiolane 2-oxides. These compounds were also obtained from 4-chloromethyl-1,3,2-dioxathiolane 2-oxides by substitution aryloxy group for chlorine. The cyclic sulfides synthesized are universal intermediates in the synthesis of chiral aryloxypropanolamines among which are known β-adrenoblockaders, cardiovascular drugs. From (S)-glycidol, (S)-alprenolol, (S)-propanolol, and (S)-thymolol were synthesized.