476187-10-7Relevant articles and documents
Synthesis of enantiopure cis- and trans-2,3-disubstituted piperidines
Agami, Claude,Dechoux, Luc,Menard, Cecilia,Hebbe, Severine
, p. 7573 - 7576 (2007/10/03)
The synthesis of enantiopure cis- and trans-2,3-disubstituted piperidines 4 is described. The key step of the synthesis involves the stereoselective reduction of chiral nonracemic lactams 2 by using BH3·Me2S. A rationalization of the stereoselectivity is presented.