595582-07-3

Basic information

• Product Name: 3-Pyridinecarboxylic acid, 1,4,5,6-tetrahydro-1-[(1S)-2-hydroxy-1-phenylethyl]-2-methyl-6-oxo-, methyl ester
• CAS NO: 595582-07-3
• Molecular Formula: C16H19NO4
• Molecular Weight: 289.331
• Mol File: 595582-07-3.mol

Chemical Properties

• CAS DataBase Reference: 3-Pyridinecarboxylic acid, 1,4,5,6-tetrahydro-1-[(1S)-2-hydroxy-1-phenylethyl]-2-methyl-6-oxo-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pyridinecarboxylic acid, 1,4,5,6-tetrahydro-1-[(1S)-2-hydroxy-1-phenylethyl]-2-methyl-6-oxo-, methyl ester(595582-07-3)
• EPA Substance Registry System: 3-Pyridinecarboxylic acid, 1,4,5,6-tetrahydro-1-[(1S)-2-hydroxy-1-phenylethyl]-2-methyl-6-oxo-, methyl ester(595582-07-3)

Safety Data

• Hazardous Substances Data: 595582-07-3(Hazardous Substances Data)

Upstream product

• 595582-03-9 1-[2-(tert-butyl-dimethyl-silanyloxy)-(1S)-phenyl-ethyl]-2-methyl-6-oxo-1,4,5,6-tetrahydro-pyridine-3-carboxylic acid methyl ester 
• 20989-17-7 (2S)-2-phenylglycinol 
• 725250-70-4 (Z)-3-[(S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-phenyl-ethylamino]-but-2-enoic acid methyl ester 
• 105-45-3 acetoacetic acid methyl ester 
• 120417-13-2 (S)-2-(tert-butyldimethylsilyloxy)-1-phenylethylamine 
• 814-68-6 acryloyl chloride 
• 476187-10-7 (Z)-3-((S)-2-Hydroxy-1-phenyl-ethylamino)-but-2-enoic acid methyl ester 

Downstream Products

• 454451-67-3 (3S)-(8S)-(8aR)-methyl-5-oxo-3-phenyl-hexahydro-oxazolo[3,2-a]pyridine-8-carboxylic acid methyl ester 
• 454451-70-8 (3S)-(8R)-(8aR)-methyl-5-oxo-3-phenyl-hexahydro-oxazolo[3,2-a]pyridine-8-carboxylic acid methyl ester 
• 476187-19-6 (1S)-(2S)-(3S)-1-(2-hydroxy-1-phenyl-ethyl)-2-methyl-piperidine-3-carboxylic acid methyl ester 

Relevant articles and documents

Enantioselective synthesis of indolizidine and quinolizidine derivatives from chiral non-racemic bicyclic lactams

Chiral non-racemic bicyclic lactams 2b,c, derived from (R)- and (S)-phenylglycinol, were used in the enantioselective synthesis of (-)-lupinine and 5-epitashiromine, respectively. The efficiency of the synthesis relied on the high diastereoselectivities of formation and reduction of compounds 2b,c.

A novel stereocontrolled synthesis of enantiopure bicyclic lactams

A study on the reactivity of 3,4-dihydro-2-pyridones 9, derived from (S)-phenylglycinol, toward different bases is presented. Using a catalytic amount of bases, the cis bicyclic lactams were obtained with excellent diastereoselectivities.

Asymmetric synthesis of nitrogen heterocycles by reaction of chiral β-enaminocarbonyl substrates with acrylate derivatives

We have studied the reactivity of β-enaminoesters 1 (R2=OMe) or β-enaminoketone 1 (R2=Me), derived from (S)-phenylglycinol, with activated acrylate derivatives. Substrates 1 (R1=Me) afforded by aza-annulation oxazololactam