476192-97-9

Upstream product

• 1310570-15-0 4-[[4-(3-carboxypropoxy)phenyl] sulfonyl]tetrahydro-2H-pyran-4-carboxylic acid 1,1-dimethylethyl ester 

Downstream Products

• 476192-99-1 C₂₈H₃₁F₃N₂O₈S 
• 476193-01-8 C₂₄H₂₃F₃N₂O₈S 
• 476193-03-0 C₂₉H₃₂F₃N₃O₉S 
• 476185-58-7 tetrahydro-N-hydroxy-4-[[4-[3-[3[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl]propoxy]phenyl]sulfonyl]-2H-pyran-4-carboxamide 

Relevant academic research and scientific papers

MMP-13 selective α-sulfone hydroxamates: A survey of P1′ heterocyclic amide isosteres

Seeking compounds preferentially potent and selective for MMP-13, we reported in the preceding Letter on a series of hydroxamic acids with a flexible benzamide tail groups.1a Here, we replace the amide moiety with non-hydrolyzable heterocycles

Aromatic sulfone hydroxamates and their use as protease inhibitors

This invention is directed to aromatic sulfone hydroxamates (also known as “aromatic sulfone hydroxamic acids”) and salts thereof that, inter alia, inhibit matrix metalloproteinase (also known as “matrix metalloprotease” or “MMP”) activity and/or aggrecanase activity. This invention also is directed to a prevention or treatment method that comprises administering such a compound or salt in an MMP-inhibiting and/or aggrecanase-inhibiting effective amount to an animal, particularly a mammal having (or disposed to having) a pathological condition associated with MMP and/or aggrecanase activity.