47626-99-3Relevant academic research and scientific papers
Design, synthesis and biological evaluation of benzylisoquinoline derivatives as multifunctional agents against Alzheimer's disease
Xu, Zi-Chen,Wang, Xiao-Bing,Yu, Wen-Ying,Xie, Sai-Sai,Li, Su-Yi,Kong, Ling-Yi
, p. 2368 - 2373 (2014/05/20)
A novel series of benzylisoquinoline derivatives were designed, synthesized, and evaluated as multifunctional agents against Alzheimer's disease (AD). The screening results showed that most of the compounds significantly inhibited cholinesterases (ChEs),
Total synthesis of new 8-(arylmethyl)berbines
Valpuesta, Maria,Ariza, Manuela,Diaz, Amelia,Torres, Gregorio,Suau, Rafael
experimental part, p. 638 - 645 (2010/03/30)
The total synthesis of the natural compound (8S*, 14S*)-8-(4'hydroxybenzyl)-2,3-dimethoxyberbin-10-ol and its C-8 epimer has been conveniently developed by making use of the diastereoselective Stevens rearrangement of the corresponding N-(arylmethyl)berbi
Enantioselective synthesis of the tetrahydrobenzyl-isoquinoline alkaloid (-)-norarmepavine using polymer supported reagents
Baxendale, Ian R.,Davidson, Thomas D.,Ley, Steven V.,Perni, Remedios H.
, p. 2707 - 2715 (2007/10/03)
We describe, in full, the enantioselective synthesis of the tetrahydrobenzylisoquinoline alkaloid (-)-norarmepavine (1) in 77% e.e. This compound was prepared using solid-supported reagents and scavengers in multi-step sequences of reactions to give mater
