5884-31-1

Upstream product

• 6547-53-1 2-[4-(benzyloxy)benzyl]acetic acid 
• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 156-38-7 4-hydroxyphenylacetate 
• 10214-84-3 N-[2-(3,4-dimethoxyphenyl)ethyl]-2-(4-hydroxyphenyl)acetamide 
• 100-39-0 benzyl bromide 
• 56441-69-1 2-<4-(phenylmethoxy)phenyl>acetic acid ethyl ester 

Downstream Products

• 3195-01-5 L-(-)-N-norarmepavine 
• 655245-11-7 1-(4-benzyloxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline 
• 115385-69-8 1-(4-benzyloxybenzyl)-6,7-dimethoxy-3,4-dihydroisoquinolinium chloride 
• 1609169-63-2 tert-butyl 1-(4-((5-bromopentyl)oxy)benzyl)-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-carboxylate 
• 1609169-62-1 tert-butyl 1-(4-(4-bromobutoxy)benzyl)-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-carboxylate 
• 1609169-61-0 tert-butyl 1-(4-(3-bromopropoxy)benzyl)-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-carboxylate 
• 1609169-60-9 tert-butyl 1-(4-hydroxybenzyl)-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-carboxylate 
• 3472-22-8 N-norarmepavine 
• 1609169-53-0 6,7-dimethoxy-1-(4-((6-(4-phenylpiperidin-1-yl)hexyl)oxy)benzyl)-1,2,3,4-tetrahydroisoquinoline 
• 1609169-59-6 tert-butyl 1-(4-(benzyloxy)benzyl)-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-carboxylate 
• 1609169-52-9 1-(4-((6-(4-benzylpiperazin-1-yl)hexyl)oxy)benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline 
• 1609169-51-8 6,7-dimethoxy-1-(4-((6-(4-phenylpiperazin-1-yl)hexyl)oxy)benzyl)-1,2,3,4-tetrahydroisoquinoline 
• 1609169-50-7 4-benzyl-1-(6-(4-((6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl)phenoxy)hexyl)piperidin-4-ol 
• 1609169-49-4 4-(6-(4-((6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl)phenoxy)hexyl)morpholine 

Relevant academic research and scientific papers

Application of differential reactivity towards synthesis of lamellarin and 8-oxoprotoberberine derivatives: Study of photochemical properties of aryl-substituted benzofuran-8-oxoprotoberberines

A unique differential reactivity between dihydroisoquinolines and 3-nitrocoumarins was observed and was exploited for the efficient construction of lamellarins and their isomeric benzofuran-8-oxoprotoberberine derivatives under acid-catalyzed or base-promoted conditions. Further, these prepared aryl-substituted benzofuran-8-oxoprotoberberine derivatives bearing electron-donating substituents on benzofuran moiety are found to be benchtop stable but light-sensitive, and can undergo oxidative ring-opening reaction to give the corresponding keto products when exposed to visible light under aerobic conditions.

Design, synthesis and biological evaluation of benzylisoquinoline derivatives as multifunctional agents against Alzheimer's disease

A novel series of benzylisoquinoline derivatives were designed, synthesized, and evaluated as multifunctional agents against Alzheimer's disease (AD). The screening results showed that most of the compounds significantly inhibited cholinesterases (ChEs),

Total synthesis of new 8-(arylmethyl)berbines

The total synthesis of the natural compound (8S*, 14S*)-8-(4'hydroxybenzyl)-2,3-dimethoxyberbin-10-ol and its C-8 epimer has been conveniently developed by making use of the diastereoselective Stevens rearrangement of the corresponding N-(arylmethyl)berbi

Enantioselective synthesis of the tetrahydrobenzyl-isoquinoline alkaloid (-)-norarmepavine using polymer supported reagents

We describe, in full, the enantioselective synthesis of the tetrahydrobenzylisoquinoline alkaloid (-)-norarmepavine (1) in 77% e.e. This compound was prepared using solid-supported reagents and scavengers in multi-step sequences of reactions to give mater