476352-17-7

Basic information

• Product Name: N-methyl-2-(4',6'-dimethoxy-3'-phenylbenzofuran-2'-yl)-2-hydroxyethanamide
• Synonyms: N-methyl-2-(4',6'-dimethoxy-3'-phenylbenzofuran-2'-yl)-2-hydroxyethanamide
• CAS NO: 476352-17-7
• Molecular Weight: 341.364
• Mol File: 476352-17-7.mol

Chemical Properties

• CAS DataBase Reference: N-methyl-2-(4',6'-dimethoxy-3'-phenylbenzofuran-2'-yl)-2-hydroxyethanamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-methyl-2-(4',6'-dimethoxy-3'-phenylbenzofuran-2'-yl)-2-hydroxyethanamide(476352-17-7)
• EPA Substance Registry System: N-methyl-2-(4',6'-dimethoxy-3'-phenylbenzofuran-2'-yl)-2-hydroxyethanamide(476352-17-7)

Safety Data

• Hazardous Substances Data: 476352-17-7(Hazardous Substances Data)

Upstream product

• 108838-36-4 4,6-dimethoxy-3-phenylbenzofuran 
• 476352-08-6 N-methyl-2-(4',6'-dimethoxy-3'-phenylbenzofuran-2'-yl)glyoxylamide 

Relevant articles and documents

Acid-catalysed reactions of activated benzofuranylmethanols: Formation of calixbenzofurans

Regiochemistry of electrophilic substitution of the 3-substituted-4,6-dimethoxybenzofurans is largely controlled by the substituents at C3. The presence of a 3-aryl group results in the preferred formation of 2-substituted benzofuran derivatives whereas a bulky tert-butyl 3-substituent leads to a dominance of 7-substituted products. Acid-catalysed reactions of 2-hydroxymethylbenzofurans give mainly unsymmetrically linked calix[3]benzofurans. However, acid treatment of 7-hydroxymethylbenzofurans affords only the symmetrically linked calix[3]benzofurans in high yields. Benzofuranyl glyoxylamides, glyoxylates and ketones can be obtained in high yields and the acid-catalysed reactions of their corresponding alcohol reduction products generally give moderate to high yields of the symmetrically linked calix[3]benzofurans together with a minor amount of a calix[4]benzofuran.