476373-78-1

Basic information

• Product Name: Cyclohexanone, 4-phenyl-, O-methyloxime
• CAS NO: 476373-78-1
• Molecular Formula: C13H17NO
• Molecular Weight: 203.284
• Mol File: 476373-78-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Cyclohexanone, 4-phenyl-, O-methyloxime(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexanone, 4-phenyl-, O-methyloxime(476373-78-1)
• EPA Substance Registry System: Cyclohexanone, 4-phenyl-, O-methyloxime(476373-78-1)

Safety Data

• Hazardous Substances Data: 476373-78-1(Hazardous Substances Data)

Upstream product

• 4500-20-3 4-phenylcyclohexanone oxime 
• 593-56-6 N-methoxylamine hydrochloride 
• 67-56-1 methanol 
• 4894-75-1 1-phenyl-4-cyclohexanone 

Relevant articles and documents

Titanium-Mediated Synthesis of Spirocyclic NH-Azetidines from Oxime Ethers

The TiIV-mediated synthesis of spirocyclic NH-azetidines from oxime ethers using either an alkyl Grignard reagent or terminal olefin ligand exchange coupling partner is described. Through a proposed Kulinkovich-type mechanism, a titanacyclopropane intermediate forms and serves as a 1,2-aliphatic dianion equivalent, inserting into the 1,2-dielectrophilc oxime ether to ultimately give rise to the desired N-heterocyclic four-membered ring. This transformation proceeds in moderate yield to furnish previously unreported and structurally diverse NH-azetidines in a single step.

Spiro and dispiro 1,2,4-trioxolane antimalarials

A means and method for treating malaria using a spiro or dispiro 1,2,4-trioxolane is described. The preferred 1,2,4-trioxolanes include a spiroadamantane group on one side of the trioxolane group, and a spirocyclohexyl or spiropiperidyl ring on the other side of the trioxolane group, whereby the spirocyclohexyl ring is preferably functionalized or substituted at the 4-position or a spiropiperidyl ring that is functionalized or substituted at the nitrogen atom. In comparison to artemisinin semisynthetic derivatives, the compounds of this invention are structurally simple, easy to synthesize, non-toxic, and potent against malarial parasites.